Volume 11, Number 6—June 2005
Research
Global Spread of Vancomycin-resistant Enterococcus faecium from Distinct Nosocomial Genetic Complex
Rob J.L. Willems*
, Janetta Top*, Marga van Santen†, D. Ashley Robinson‡, Teresa M. Coque§, Fernando Baquero§, Hajo Grundmann†, and Marc J.M. Bonten*
, Janetta Top*, Marga van Santen†, D. Ashley Robinson‡, Teresa M. Coque§, Fernando Baquero§, Hajo Grundmann†, and Marc J.M. Bonten*Table 3
Variant alleles of single locus variants (SLVs) within 5 genetic complexes*
| ST of ancestor | ST of SLV | Variant locus | Ancestral allele | SLV allele | No. nucleotide differences (amino acid change) |
|---|---|---|---|---|---|
| 17 | 64 | atpA | 1 | 7 | 4 |
| 17 | 117 | atpA | 1 | 9 | 20 |
| 17 | 78 | atpA | 1 | 15 | 22 |
| 17 | 16 | ddl | 1 | 2 | 1 |
| 17 | 63 | purK | 1 | 21 | 1 (C-Y)† |
| 17 | 174 | purK | 1 | 29 | 1† |
| 22 | 32 | atpA | 2 | 3 | 2 |
| 22 | 21 | atpA | 2 | 9 | 18 |
| 22 | 92 | atpA | 2 | 5 | 19 |
| 22 | 71 | atpA | 2 | 15 | 20 |
| 22 | 135 | atpA | 2 | 27 | 18 |
| 22 | 159 | atpA | 2 | 30 | 1† |
| 22 | 113 | atpA | 2 | 26 | 19 |
| 22 | 55 | ddl | 3 | 1 | 6 |
| 22 | 111 | gdh | 1 | 6 | 1 |
| 22 | 24 | purK | 2 | 7 | 3 |
| 22 | 136 | purK | 2 | 26 | 1 (H-Y)† |
| 22 | 33 | pstS | 1 | 5 | 1 (L-V)† |
| 22 | 23 | adk | 1 | 7 | 1† |
| 1 | 43 | atpA | 8 | 3 | 16 |
| 1 | 41 | purK | 7 | 3 | 4 |
| 1 | 2 | gyd | 1 | 9 | 1 (Y-H)† |
| 1 | 3 | pstS | 1 | 12 | 1 (Y-N)† |
| 94 | 40 | atpA | 13 | 10 | 3 |
| 94 | 60 | gyd | 6 | 11 | 1 |
| 94 | 61 | pstS | 10 | 17 | 4 |
| 94 | 178 | pstS | 10 | 27 | 2 |
| 69 | 46 | atpA | 9 | 5 | 1 |
| 69 | 161 | atpA | 9 | 3 | 16 |
| 69 | 47 | adk | 6 | 5 | 4 |
*Genetic complexes 1, 17, 22, 69, and 94 were included in this analysis. ST, sequence type; C, cysteine; Y, tyrosine; H, histidine; L, leucine; V, valine; N, asparagine.
†Single nucleotide changes that are unique in the dataset and thus are due to mutation.
