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Volume 11, Number 6—June 2005

Research

Global Spread of Vancomycin-resistant Enterococcus faecium from Distinct Nosocomial Genetic Complex

Rob J.L. Willems*Comments to Author , Janetta Top*, Marga van Santen†, D. Ashley Robinson‡, Teresa M. Coque§, Fernando Baquero§, Hajo Grundmann†, and Marc J.M. Bonten*
Author affiliations: *University Medical Center Utrecht, Utrecht, the Netherlands; †National Institute for Public Health and the Environment, Bilthoven, the Netherlands,; ‡New York Medical College, Valhalla, New York, USA; §Hospital Ramon y Cajal, Madrid, Spain

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Table 3

Variant alleles of single locus variants (SLVs) within 5 genetic complexes*

ST of ancestor ST of SLV Variant locus Ancestral allele SLV allele No. nucleotide differences
(amino acid change)
17 64 atpA 1 7 4
17 117 atpA 1 9 20
17 78 atpA 1 15 22
17 16 ddl 1 2 1
17 63 purK 1 21 1 (C-Y)†
17 174 purK 1 29 1†
22 32 atpA 2 3 2
22 21 atpA 2 9 18
22 92 atpA 2 5 19
22 71 atpA 2 15 20
22 135 atpA 2 27 18
22 159 atpA 2 30 1†
22 113 atpA 2 26 19
22 55 ddl 3 1 6
22 111 gdh 1 6 1
22 24 purK 2 7 3
22 136 purK 2 26 1 (H-Y)†
22 33 pstS 1 5 1 (L-V)†
22 23 adk 1 7 1†
1 43 atpA 8 3 16
1 41 purK 7 3 4
1 2 gyd 1 9 1 (Y-H)†
1 3 pstS 1 12 1 (Y-N)†
94 40 atpA 13 10 3
94 60 gyd 6 11 1
94 61 pstS 10 17 4
94 178 pstS 10 27 2
69 46 atpA 9 5 1
69 161 atpA 9 3 16
69 47 adk 6 5 4

*Genetic complexes 1, 17, 22, 69, and 94 were included in this analysis. ST, sequence type; C, cysteine; Y, tyrosine; H, histidine; L, leucine; V, valine; N, asparagine.
†Single nucleotide changes that are unique in the dataset and thus are due to mutation.

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