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Volume 12, Number 10—October 2006

Research

Active Cytomegalovirus Infection in Patients with Septic Shock

Lutz von Müller*, Anke Klemm*, Manfred Weiss*, Marion Schneider*, Heide Suger-Wiedeck*, Nilgün Durmus*, Walter Hampl*, and Thomas Mertens*Comments to Author 
Author affiliations: *University Hospital Ulm, Ulm, Germany

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Table

Characteristics and clinical course of patients with septic shock, with and without active CMV infection*

Active CMV infection No active CMV infection Significance
No. patients 8 17
CMV IgG, index 12.4 (5.4–14.7) 11.7 (1.5–18.3) NS†
CMV IgM, index 0.4 (0.28–3.94) 0.28 (0.2–1.8) NS†
Sex, n
Male 5 10 NS‡
Female 3 7 NS‡
Age, y 66 (40–78) 60 (44–78) NS†
Primary condition, n
Abdominal surgery 1 7 NS‡
Abdominal tumor 1 4 NS‡
Pancreatitis 3 1 NS‡
Trauma 2 5 NS‡
Vascular surgery 1 0 NS‡
Bacteremia, n (%) 4 (50) 10 (59) NS‡
Candidemia, n (%) 2 (25) 1 (6) NS‡
SOFA score§ 10 (7–13) 10 (7–16) NS‡
Leukocyte count, g/L§ 27 (10.4–53.3) 22.4 (7.2–74.3) NS†
Platelet count, g/L¶ 106 (37–151) 112 (37–385) NS†
Serum creatinine, μmol/L§ 183 (73–345) 160 (72–347) NS†
Serum bilirubin, μmol/L§ 27 (6–279) 54 (4–336) NS†
Aspartate aminotransferase, U/L§ 55 (7–267) 45 (9–229) NS†
C-reactive protein, mg/L§ 258 (16–456) 220 (115–437) NS†
ICU stay after onset of septic shock, d 42 (16–87) 18 (10–42) p = 0.0025†
Mechanical ventilation, d 39 (15–80) 16 (5–38) p = 0.0025†
Receipt of catecholamines, d 7 (4–41) 7 (1–35) NS†
Mortality rate, n (%) 5 (63) 6 (35) NS‡
HSV reactivation, n (%) 6 (75) 2 (12) p = 0.0036‡

*Median (range), unless otherwise indicated; CMV, cytomegalovirus; Ig, immunoglobulin; NS, not significant (p>0.05); SOFA, sepsis-related organ failure assessment; ICU, intensive care unit; HSV, herpes simplex virus.
†According to Mann-Whitney U test.
‡According to Fisher exact test.
§Highest values.
¶Lowest values.

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