Emerging Infectious Disease ISSN: 1080-6059

Super-Sentinel Chickens and Detection of Low-Pathogenicity Influenza Virus

Philip I. Marcus*

, Theodore Girshick†, Louis van der Heide*, and Margaret J. Sekellick*

Author affiliations: *University of Connecticut, Storrs, Connecticut, USA; †Charles River Specific Pathogen Free Avian Supplies, Storrs, Connecticut, USA;

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Figure 1

Seroconversion in specific-pathogen-free white leghorns after infection with influenza A/CK/CT/72/2003 (H7N2) as measured by agar gel precipitin (AGP) tests for avian influenza virus nucleoprotein and M1 antigens. Each box represents 1 chicken; (–), water; (+), water plus recombinant chicken interferon-α at 2,000 U/mL. IFN, interferon; IN, intranasal; IV, intravenous. A and B are independent trials. Serum samples were obtained at the times indicated on days post infection for overtly infected birds.

Figure 1. Seroconversion in specific-pathogen-free white leghorns after infection with influenza A/CK/CT/72/2003 (H7N2) as measured by agar gel precipitin (AGP) tests for avian influenza virus nucleoprotein and M1 antigens. Each box represents 1 chicken; (–), water; (+), water plus recombinant chicken interferon-α at 2,000 U/mL. IFN, interferon; IN, intranasal; IV, intravenous. A and B are independent trials. Serum samples were obtained at the times indicated on days post infection for overtly infected birds.

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