Emerging Infectious Disease ISSN: 1080-6059

Super-Sentinel Chickens and Detection of Low-Pathogenicity Influenza Virus

Philip I. Marcus*

, Theodore Girshick†, Louis van der Heide*, and Margaret J. Sekellick*

Author affiliations: *University of Connecticut, Storrs, Connecticut, USA; †Charles River Specific Pathogen Free Avian Supplies, Storrs, Connecticut, USA;

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Figure 2

Seroconversion in sentinel specific-pathogen-free white leghorns after natural infection with influenza A/CK/CT/72/03 (H7N2) from overtly infected birds as quantified by hemagglutination inhibition (HI) tests for hemagglutinin (HA) antigen. The titer in HI U/mL is plotted as a function of days post overt infection of 2 birds in each group. The key is similar to that of Figure 1, except the assay is for HI. A, water only; B, water plus recombinant chicken interferon-α at 2,000 U/mL. Results of 1 trial are shown; 2 other trials gave similar results.

Figure 2. Seroconversion in sentinel specific-pathogen-free white leghorns after natural infection with influenza A/CK/CT/72/03 (H7N2) from overtly infected birds as quantified by hemagglutination inhibition (HI) tests for hemagglutinin (HA) antigen. The titer in HI U/mL is plotted as a function of days post overt infection of 2 birds in each group. The key is similar to that of Figure 1, except the assay is for HI. A, water only; B, water plus recombinant chicken interferon-α at 2,000 U/mL. Results of 1 trial are shown; 2 other trials gave similar results.

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