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Volume 13, Number 10—October 2007

Dispatch

Chlorine Inactivation of Highly Pathogenic Avian Influenza Virus (H5N1)

Eugene W. Rice*Comments to Author , Noreen J. Adcock*, Mano Sivaganesan*, Justin D. Brown†, David E. Stallknecht†, and David E. Swayne‡
Author affiliations: *US Environmental Protection Agency, Cincinnati, Ohio, USA; †University of Georgia, Athens, Georgia, USA; ‡US Department of Agriculture, Athens, Georgia, USA;

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Table 1

Ct values (mg-min/L) for inactivation of HPAI (H5N1) virus by free chlorine at 5ºC*

Strain
pH
Log10 inactivation
1.0
2.0
3.0
Hong Kong† 7 0.14 0.27 0.41
8 0.26 0.53 0.79
Mongolia‡ 7 0.13 0.26 0.39
8 0.23 0.46 0.68

*Ct, 0.5(C0 + C0.5)/2 + C0.5 [1–exp (–k (t–0.5) ]/k, where C0 = chlorine concentration at time zero (mg/L); C0.5, chlorine concentration at 0.5 min (mg/L); k, exponential chlorine decay rate; t = time (min). HPAI, highly pathogenic avian influenza.
†A/chicken/Hong Kong/D-0947/2006.
‡A/WhooperSwan/Mongolia/244/2005.

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