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Volume 13, Number 10—October 2007

Dispatch

Chlorine Inactivation of Highly Pathogenic Avian Influenza Virus (H5N1)

Eugene W. Rice*Comments to Author , Noreen J. Adcock*, Mano Sivaganesan*, Justin D. Brown†, David E. Stallknecht†, and David E. Swayne‡
Author affiliations: *US Environmental Protection Agency, Cincinnati, Ohio, USA; †University of Georgia, Athens, Georgia, USA; ‡US Department of Agriculture, Athens, Georgia, USA;

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Table 2

Inactivation of HPAI (H5N1) virus by free chlorine at 5°C*

Strain pH Time, s Free chlorine, mg/L Virus titer log10 TCID50/mL Log10 reduction
Hong Kong† 7 0 2.08 5.32 NA
15 ND <2.17 >3.15
30 0.65 <2.17 >3.15
60 0.52 <2.17 >3.15
8 0 2.08 5.70 NA
15 ND 3.88 1.82
30 0.76 2.67 3.03


60
0.59
<2.17
>3.53
Mongolia‡ 7 0 1.86 5.26 NA
15 ND <2.17 >3.09
30 0.85 <2.17 >3.09
60 0.77 <2.17 >3.09
8 0 2.04 5.53 NA
15 ND 3.39 2.14
30 1.10 <2.17 >3.36
60 1.08 <2.17 >3.36

*HPAI, highly pathogenic avian influenza; TCID50, median 50% tissue culture infectious dose; NA, not applicable; ND, not determined.
†A/chicken/Hong Kong/D-0947/2006.
‡A/WhooperSwan/Mongolia/244/2005.

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