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Volume 13, Number 10—October 2007

Dispatch

Duration of Antibody Responses after Severe Acute Respiratory Syndrome

Li-Ping Wu*, Nai-Chang Wang*, Yi-Hua Chang*, Xiang-Yi Tian*, Dan-Yu Na*, Li-Yuan Zhang*, Lei Zheng*, Tao Lan†, Lin-Fa Wang‡, and Guo-Dong Liang§Comments to Author 
Author affiliations: *Shanxi Provincial Center for Disease Control and Prevention, Taiyuan, People’s Republic of China; †Shanxi Provincial Peoples’ Hospital, Taiyuan, People’s Republic of China; ‡CSIRO Australian Animal Health Laboratory and Australian Biosecurity Center for Emerging Infectious Diseases, Geelong, Victoria, Australia; §State Key Laboratory for Infectious Disease Control and Prevention, Beijing, People’s Republic of China;

Main Article

Table

Cumulative rates of SARS-CoV antibodies among 176 SARS patients with known transmission histories*

Time after symptom onset, d IgG
IgM†
No. samples tested No. positive samples (%) Average OD No. samples 
tested No. positive samples (%) Average OD
0–7 17 2 (11.76) 0.046 14 3 (21.43) 0.136
8–14 26 10 (38.46) 0.190 22 14 (63.64) 0.312
15–20 22 17 (77.27) 0.351 19 12 (63.16) 0.477
21–30 36 33 (91.67) 0.493 21 16 (76.19) 0.560
31–60 72 67 (93.06) 0.627 22 14 (63.64) 0.320
61–90 35 33 (94.29) 0.745 15 5 (33.33) 0.167
91–120 11 11 (100.00) 0.965 ND ND ND
121–210 23 23 (100.00) 0.932 ND ND ND
211–365 49 46 (93.88) 0.734 ND ND ND
366–763 96 86 (89.58) 0.535 ND ND ND
764–1,265 28 15 (53.57) 0.250 ND ND ND

*SARS-CoV, severe acute respiratory syndrome–associated coronavirus; Ig, immunoglobulin; OD, optical density; ND, not determined because for most samples the IgM readings already reached background level on day 90.
†For some patients, we did not have enough serum to test for IgM after testing for IgG; hence, a smaller number of serum samples were tested for IgM than for IgG.

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