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Volume 13, Number 11—November 2007

Dispatch

Characterization of Hemorrhagic Fever with Renal Syndrome Caused by Hantaviruses, Estonia

Irina Golovljova*†‡, Veera Vasilenko*, Vassili Mittženkov*, Tiina Prükk§, Elviira Seppet§, Sirkka Vene†, Bo Settergren¶, Alexander Plyusnin†#, and Åke Lundkvist†‡Comments to Author 
Author affiliations: *National Institute for Health Development, Tallinn, Estonia; †Swedish Institute for Infectious Disease Control, Solna, Sweden; ‡Karolinska Institutet, Stockholm, Sweden; §University of Tartu, Tartu, Estonia; ¶Central Hospital, Kristianstad, Sweden; #University of Helsinki, Helsinki, Finland;

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Table 1

Hantavirus-specific antibodies in 30 HFRS patients in Estonia as determined by ELISA and FRNT*

Patient no. ELISA
FRNT of convalescent-phase serum
Time after onset, d PUUV IgM/IgG SAAV IgM/IgG Time after onset PUUV SAAV DOBV SEOV
681 13 1.095/0.556† 0.075/0 5 mo 640‡ 40 <40 <40
715 12 1.147/0.258 0.052/0.045 21 d 640 <40 <40 <40
716 17 1.072/0.383 0.028/0 1 mo 2,560 <40 <40 <40
718 7 1.079/0.142 0/0.019 1 mo 2,560 <40 <40 <40
728 24 0.602/0.727 0.039/0.145 9 mo 640 <40 <40 <40
731 8 1.43/0.309 0/0.102 24 d 2,560 <40 <40 <40
761 9 1.048/0.213 0.034/0.138 ND ND ND ND ND
763 9 1.309/0.631 0.031/0.088 ND ND ND ND ND
766 15 1.340/0.586 0.036/0.043 7 mo 640 <40 <40 <40
767 16 1.840/0.627 0.040/0.034 12 mo 640 <40 <40 <40
770 13 0.995/0.127 0.231/0.031 5 mo 160 <40 <40 <40
772 6 0.331/0.044 0.137/0.021 11 mo 160 <40 <40 <40
774 4 1.361/0.863 0.103/0.088 11 mo 160 <40 40 <40
800 8 1.151/0.152 0/0.099 ND ND ND ND ND
812 9 1.144/0.244 0.026/0.046 9 mo 640 <40 <40 <40
813 7 1.058/0.089 0.082/0.06 2 mo 640 <40 <40 <40
840 8 0.724/0.038 0.083/0.055 9 mo 640 <40 <40 <40
841 8 0.704/0.142 0.073/0.013 20 d 2,560 160 160 <40
855 24 0.791/0.152 0.632/0.090 1 mo 640 40 40 <40
857 5 1.133/0.043 1.053/0.067 ND ND ND ND ND
861 23 1.051/0.184 0.559/0.035 1.5 mo 640 <40 <40 <40
895 5 0.957/0.135 ND/0.011 1 mo 2,560 <40 <40 <40
899 13 0.797/0.120 ND/0.005 1.5 mo 160 <40 <40 <40
927 11 0.833/0.279 ND/0.004 1.5 mo 640 <40 40 <40
933 5 0.569/0.464 ND/0.116 18 mo 160 <40 40 <40
691 6 0.355/0.047 1.014/0.081 4 mo <40 160 40 <40
769 10 0.271/0 0.218/0.254 20 d <40 2,560 640 <40
801 14 0/0.038 0.394/1.548 1.5 mo <40 640 160 <40
849 4 0.011/0 0.599/0.133 ND ND ND ND ND
795 12 0.144/0 0.442/362 11 mo <40 160 640 <40

*HFRS, hemorrhagic fever with renal syndrome; FRNT, focus reduction neutralization test; PUUV, Puumala virus; SAAV, Saaremaa virus; Ig, immunoglobulin; DOBV, Dobrava virus; SEOV, Seoul virus; ND, not done. Numbers in boldface indicated positive results in ELISA and at least 4-fold higher titer in FRNT. The cut-off value for ELISA was set at OD = 0.100.
†Mean optical density (OD) for duplicate samples.
‡Reciprocal endpoint titer at an 80% reduction.

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