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Volume 13, Number 11—November 2007

Research

Protection and Virus Shedding of Falcons Vaccinated against Highly Pathogenic Avian Influenza A Virus (H5N1)

Michael Lierz*Comments to Author , Hafez M. Hafez*, Robert Klopfleisch†, Dörte Lüschow*, Christine Prusas*, Jens P. Teifke†, Miriam Rudolf†, Christian Grund†, Donata Kalthoff†, Thomas Mettenleiter†, Martin Beer†, and Timm Harder†
Author affiliations: *Freie Universität, Berlin, Germany; †Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany;

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Table 1

Titers (log2) of hemagglutination-inhibiting antibodies against homologous influenza H5 antigen in 10 Gyr-Saker hybrid falcons after vaccination*

Falcon no., vaccination route Titer at 0–8 weeks after vaccination
0† 1 2 3 4‡ 5 6 7 8
1, IM 0 0 0 2 4 5 6 6 7
2, IM 0 0 0 2 3 4 6 8 9
3, IM 0 0 0 2 5 6 7 8 8
4, IM 0 0 0 3 4 4 6 7 6
5, IM 0 0 0 0 0 0 3 3 3
6, SC 0 0 0 3 4 5 6 8 7
7, SC 0 0 0 2 3 4 6 8 7
8, SC 0 0 0 3 3 4 5 6 7
9, SC 0 0 0 2 4 6 6 7 7
10, SC 0 0 0 3 4 5 6 6 6

*Vaccination with an inactivated influenza (H5N2) vaccine (strain A/duck/Potsdam/1402/86) at a dose of 0.5 mL containing >4 log2 hemagglutinating units. IM, intramuscular; SC, subcutaneous.
†Time of first vaccination.
‡Time of booster vaccination.

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