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Volume 13, Number 2—February 2007

Research

Community-associated Methicillin-resistant Staphylococcus aureus Isolates and Healthcare-Associated Infections1

Cynthia L. Maree*, Robert S. Daum†, Susan Boyle-Vavra†, Kelli Matayoshi‡2, and Loren G. Miller*‡Comments to Author 
Author affiliations: *David Geffen School of Medicine at the University of California, Los Angeles, California, USA; †University of Chicago, Chicago, Illinois, USA; ‡Los Angeles Biomedical Institute at Harbor-UCLA Medical Center, Torrance, California, USA;

Main Article

Table 1

Patients with healthcare-associated MRSA isolates, 1999–2004, and predictors of SCCmec type IV phenotype*

CharacteristicPatients with HA-MRSA
Isolates, % (no.)SCCmec phenotype,% (no.)
Predictors of SCCmec type IV phenotype
Bivariate anaylsis
Multivariate analysis
Type IVType II/IIIOdds ratio
(95% CI)p valueOdds ratio (95% CI)p value
Total
(352)
36 (128)
64 (224)




Sex
F
35 (123)
36 (44)
64 (79)

0.87
>0.05
M
65 (229)
37 (84)
63 (145)


Age, y
Mean
50 ± 19 SD
47±1.7 SE
51±1.3 SE
0.02
>0.05
Median (range)
50 (<1–97)
48 (<1–87)
54 (<1–97)




Time from admission to specimen collection, d
Mean
19 ± 21 SD
15±1.9 SE
21±1.4 SE
0.01
0.88 (0.8–0.98)†
0.02
Median (range)
12 (4–184)
8 (4–174)
15 (4–184)




Culture specimen source
Blood
10 (35)
46 (16)
54 (19)
2.6 (1.2–5.7)0.02
2.2 (0.97–5.0)0.058
Sputum
34 (188)
25 (29)
75 (89)
Reference
Reference
Wound
38 (133)
49 (65)
51 (68)
2.9 (1.7–5.0)<0.0001
2.6 (1.5–4.6)0.001
Other
19 (66)
27 (18)
73 (48)
1.2 (0.6–2.3)
0.69
1.1 (0.5–2.2)
0.82
Year culture specimen collected
1999
52 (15)
17 (9)
83 (43)
Reference
<0.0001‡
Reference
<0.0001
2000
57 (16)
19 (11)
81 (46)
1.1 (0.4–3.0)

NS§
2001
65 (19)
28 (18)
72 (47)
1.8 (0.7–4.5)
1.8 (0.9–3.7)
2002
47 (13)
43 (20)
57 (27)
3.5 (1.4–8.9]
3.2 (1.5–6.9)
2003
63 (18)
56 (35)
44 (28)
6.0 (2.4–14.3)
5.2 (2.5–10.5)
200468 (19)52 (35)48(33)5.1 (2.1–12)4.4 (2.2–8.8)

*MRSA, methicillin-resistant Staphylococcus aureus; HA, healthcare associated; CI, confidence interval; SD, standard deviation; SE, standard error; NS, not significant; boldface indicates significance.
†Multivariate analysis results reflect time in weeks.
‡Measured with the Cochran-Armitage test of trends.
§Was not a significant predictor in the multivariate model.

Main Article

1Findings from this investigation were presented in part at the 45th Annual International Conference on Antimicrobial Agents and Chemotherapy, Washington, DC, USA, December 2005.

2Current affiliation: University of Southern California School of Pharmacy, Los Angeles, California

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