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Volume 13, Number 3—March 2007

Research

Effectiveness of Neuraminidase Inhibitors for Preventing Staff Absenteeism during Pandemic Influenza

Vernon J. Lee*Comments to Author  and Mark I. Chen*

Author affiliations: *Tan Tock Seng Hospital, Singapore;

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Table 2

Effects of influenza pandemic prevention strategies on healthcare worker absenteeism

Reproductive no. (R0)
Pandemic duration, wk
Peak % absent by strategy
(days with >5% absent)
No action
Treatment only
2 weeks’ prophylaxis
4 weeks’ prophylaxis
6 weeks’ prophylaxis
8 weeks’ prophylaxis
1.5242.8 (0)2.1 (0)2.1 (0)2.1 (0)2.2 (0)2.3 (0)
2156.7 (17.8)5.1 (5.4)5.2 (6.5)5.5 (9.1)5.9 (11))4.6 (0)
2.51210.2 (21.1)7.9 (16)8.1 (16.2)8.8 (16.2)7.2 (10.8)2 (0)
31013 (20.6)10.2 (16.6)10.6 (16.7)11.4 (15)4.7 (0)2.5 (0)
4817.3 (18.7)13.9 (15.7)14.6 (15.4)10.8 (11.1)3.7 (0)3.7 (0)
6622.5 (16.5)18.5 (13.9)19.7 (12.9)5.5 (4.1)5.5 (4.1)5.5 (4.1)
Pandemic similar to 1918 “Spanish flu”*20.2 (28.6)15.1 (18.3)15.8 (17.9)11.6 (13)4.1 (0)4.1 (0)

*R0 =4; mortality rate = 5% (hospitalization set to the ratio of the hospitalization rates to the case-fatality rates in Table 1).

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