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Volume 13, Number 3—March 2007

Dispatch

Depression after Infection with West Nile Virus1

Kristy O. Murray*Comments to Author , Melissa Resnick*, and Vicki Miller*
Author affiliations: *University of Texas Health Science Center, Houston, Texas, USA;

Main Article

Table

Subjective and objective measurements of depression and personality changes 1 year after clinical illness from WNV infection*

All patients (%) West Nile encephalitis
West Nile meningitis/
West Nile fever
Male (%) Female (%) Male (%) Female (%)
Measurements
  New onset depression since WNV 20/65 (31) 8/27 (30) 5/11 (45) 2/12 (17) 5/15 (33)
  Mean CES-D score for those reporting depression (range) 22 (0–44) 17 (7–30) 23 (0–37) 38 (32–43) 22 (0–44)
  CES-D score ≥15 15/20 (75) 5/8 (63) 4/5 (80) 2/2 (100) 4/5 (80)
  Taking antidepressants 7/20 (35) 3/8 (38) 1/5 (20) 1/2 (50) 2/5 (40)
  Report antidepressants helping with symptoms 4/7 (57) 2/3 (67) 1/1 (100) 0/1 (0) 1/2 (50)
  Receiving counseling 2/20 (10) 0/8 (0) 1/5 (20) 1/2 (50) 0/5 (0)
  Report counseling helping with symptoms 2/2 (100) 0 1/1 (100) 1/1 (100) 0
Personality change since WNV 29/65 (45) 12/27 (44) 6/11 (55) 4/12 (33) 7/15 (47)
  Anger/irritability/aggression 19/29 (66) 8/12 (67) 4/6 (67) 3/4 (75) 4/7 (57)
  Decreased socialization 8/29 (28) 3/12 (25) 1/6 (17) 1/4 (25) 3/7 (43)
  Increased sensitivity/cries easily 3/29 (10) 0/12 (0) 1/6 (17) 0/4 (0) 2/7 (29)
  Feelings of hopelessness 1/29 (3) 1/12 (8) 0/6 (0) 0/4 (0) 0/7 (0)

*WNV, West Nile virus; CES-D, Center for Epidemiological Studies Depression.

Main Article

1A portion of this study was presented by K. Murray at the 2006 National West Nile Virus Conference in San Francisco, California.

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