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Volume 13, Number 5—May 2007

Research

Apoptosis and Pathogenesis of Avian Influenza A (H5N1) Virus in Humans

Mongkol Uiprasertkul*, Rungrueng Kitphati†, Pilaipan Puthavathana*, Romchat Kriwong*, Alita Kongchanagul*, Kumnuan Ungchusak†, Suwimon Angkasekwinai‡, Kulkanya Chokephaibulkit*, Kanittar Srisook*, Nirun Vanprapar*, and Prasert Auewarakul*Comments to Author 
Author affiliations: *Mahidol University, Bangkok, Thailand; †Ministry of Public Health, Bangkok, Thailand; ‡Phaholpolphayuhasena Hospital, Kanjanaburi, Thailand;

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Figure 3

Terminal deoxynucleotidyl transferase–mediated dUTP-biotin nick end-labeling staining showing numerous apoptotic alveolar epithelial cells in lung of patient B (A) and leukocytes in lung of patient A (B). C) Lung tissue from a patient with pneumonia caused by human influenza A (H5N1) virus showing apoptosis only in leukocytes. D) Spleen of patient B showing numerous apoptotic cells. E) Normal spleen tissue showing only a minimal level of apoptosis. Apoptotic cells are stained dark blue and an apoptotic cell in each panel is indicated by an arrow. Magnification ×400 in A, B, and C; ×100 in D and E.

Figure 3. Terminal deoxynucleotidyl transferase–mediated dUTP-biotin nick end-labeling staining showing numerous apoptotic alveolar epithelial cells in lung of patient B (A) and leukocytes in lung of patient A (B). C) Lung tissue from a patient with pneumonia caused by human influenza A (H5N1) virus showing apoptosis only in leukocytes. D) Spleen of patient B showing numerous apoptotic cells. E) Normal spleen tissue showing only a minimal level of apoptosis. Apoptotic cells are stained dark blue and an apoptotic cell in each panel is indicated by an arrow. Magnification ×400 in A, B, and C; ×100 in D and E.

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