Volume 13, Number 5—May 2007
Letter
Expanded-spectrum β-Lactamase and Plasmid-mediated Quinolone Resistance
Laurent Poirel*
, Laura Villa†, Alessia Bertini†, Johann D. Pitout‡, Patrice Nordmann*, and Alessandra Carattoli†
, Laura Villa†, Alessia Bertini†, Johann D. Pitout‡, Patrice Nordmann*, and Alessandra Carattoli†Table
Features of the VEB-1– or QnrA-positive isolates used in this study*
| Strain†/Ref. | Spp. of origin | Country | Year of isolation | Plasmid size (kb) | ESBL | QnrA1 | Replicon | Associated non–β-lactam resistance markers |
|---|---|---|---|---|---|---|---|---|
| Escherichia coli TcE1 (5) |
E. coli |
Thailand |
1999 |
160 |
VEB-1 |
+ |
A/C2 |
NAL, K, SSS, C, RA |
| E. coli TcE4 (5) |
E. coli |
Thailand |
1999 |
150 |
VEB-1 |
+ |
A/C2 |
NAL, K, TM, SSS, C, RA |
| E. coli TcE5 (5) |
E. coli |
Thailand |
1999 |
150 |
VEB-1 |
+ |
A/C2 |
NAL, K, TM, SSS, SXT |
| E. coli TcE7 (5) |
E. coli |
Thailand |
1999 |
150 |
VEB-1 |
+ |
A/C2 |
NAL, K, TM, SSS, C, RA |
| E. coli TcE8 (5) |
E. coli |
Thailand |
1999 |
150 |
VEB-1 |
+ |
A/C2 |
NAL, K, TM, SSS, TE |
| E. coli TcE16 (5) |
E. coli |
Thailand |
1999 |
140 |
VEB-1 |
+ |
A/C2 |
NAL, K, TM, SSS, RA |
| E. coli TcE18 (5) |
E. coli |
Thailand |
1999 |
180 |
VEB-1 |
+ |
A/C2 |
NAL, K, SSS, C, RA |
| E. coli Tc(pl) (5) |
E. coli |
Canada |
2000 |
180 |
VEB-1 |
+ |
A/C2 |
NAL, K, SSS, C, RA |
| E. coli Tc(pQR1) (4) |
E. coli |
France |
2003 |
180 |
VEB-1 |
+ |
A/C2 |
NAL, K, SSS, C, RA, SXT |
| E. coli Tc(GOC) (4) |
Enterobacter cloacae |
France |
2003 |
190 |
VEB-1 |
+ |
A/C2, FIB |
NAL, K, TM, SSS, C |
| Citrobacter freundii LUT (3) |
C. freundii |
Turkey |
2004 |
ND |
VEB-1 |
+ |
A/C2, FIB, K |
NA |
| Providencia stuartii 15 (this study) |
P. stuartii |
Algeria |
2004 |
ND |
VEB-1 |
– |
A/C2 |
NA |
| E. coli TcMAA (this study) |
Proteus mirabilis |
Algeria |
2004 |
190 |
VEB-1 |
– |
A/C2 |
K, TM, SSS, C, SXT |
| E. coli TcK147 (7) |
Klebsiella pneumoniae |
Australia |
2002 |
160 |
SHV-12 |
+ |
HI2, A/C1, P |
NAL, K, TM, C, TE, SXT |
| E. cloacae A1 (8) |
E. cloacae |
France |
2004 |
75 |
SHV-12 |
+ |
HI2 |
NA |
| E. coli TcA2 (8) |
Enterobacter aerogenes |
France |
2005 |
150 |
SHV-12 |
+ |
FII |
NAL, K, TM, TE |
| E. coli TcA3 (8) | K. pneumoniae | France | 2005 | 40 | – | + | I1, K | NAL, K, TM, C, TE |
*Ref., reference; ESBL, extended-spectrum β-lactamase; NAL, nalidixic acid; K, kanamycin; SSS, sulfonamides; C, chloramphenicol; RA, rifampin; TM, tobramycin; SXT, trimethoprim-sulfamethoxazole; TE, tetracycline; ND, not determinable; NA, not applicable.
†Tc indicates that this is a transconjugant or a transformant.
