Volume 13, Number 5—May 2007
Letter
Viral Load and Crimean-Congo Hemorrhagic Fever
Anna Papa*
, Christian Drosten†, Silvia Bino‡, Εvangelia Papadimitriou*, Marcus Panning†, Enkelejda Velo‡, Majlinda Kota‡, Arjan Harxhi§, and Antonis Antoniadis*
, Christian Drosten†, Silvia Bino‡, Εvangelia Papadimitriou*, Marcus Panning†, Enkelejda Velo‡, Majlinda Kota‡, Arjan Harxhi§, and Antonis Antoniadis*Table
Epidemiologic, molecular, and clinical data for 12 Albanian patients with suspected Crimean-Congo hemorrhagic fever, 2003–2006*
| Patient |
Day of illness |
In hospital |
Outcome |
Real-time RT-PCR, geqs/reaction |
IFA |
TNF-α, pg/mL |
sTNF-R, ng/mL |
IL-6, pg/mL |
IL-10, pg/mL |
Leukocytes, × 109/L |
Platelets, × 109/L |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Group A primary | |||||||||||
| 23/03 | 6 | Yes | D | 28,990,000 | + | 68.5 | 14.0 | 109.7 | 388.3 | 1,700 | 36,200 |
| 82/03 | 5 | Yes | R | 450 | + | N | N | 17.0 | 23.9 | 2,300 | 96,830 |
| 154/04 | 18 | Yes | R | 33 | + | ND | ND | ND | ND | 15,000 | 71,400 |
| 178/04 | 4 | Yes | R | 7,271,000 | + | ND | ND | ND | 4,100 | 62,550 | |
| 252/06 |
2 |
Yes |
R |
4049 |
– |
ND |
ND |
ND |
ND |
3,700 |
117,900 |
| Group A secondary | |||||||||||
| 24b/03 | 9 | Yes | R | 166 | + | 1,444.8 | N | 114.2 | N | 4,800 | 63,800 |
| 25b/03 | 9 | Yes | R | 40 | + | N | N | 10.3 | N | 3,800 | 63,000 |
| 50/03 | 3 | No | R | 240 | – | N | N | N | 43.4 | ND | ND |
| 52/03 | 3 | No | R | 18 | – | N | N | N | 9.9 | ND | ND |
| 56/03 | 5 | No | R | 62 | + | N | N | 26.1 | N | ND | ND |
| 34/03 |
5 |
Yes |
R |
46 |
– |
N |
8.9 |
N |
N |
8,000 |
102,000 |
| Group B
secondary |
|||||||||||
| 40/03 | 7 | No | R | 14 | + | N | N | N | 23.1 | ND | ND |
*RT-PCR, reverse transcription–PCR; geqs, genome equivalents; IFA, immunofluorescent assay; TNF-α, tumor necrosis factor-α; sTNF
R, soluble TNF-α receptor; IL-6, interleukin-6; D, died; +, positive; R, recovered; N, normal value; ND, not done; –, negative.
