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Volume 13, Number 5—May 2007

Letter

Viral Load and Crimean-Congo Hemorrhagic Fever

Anna Papa*Comments to Author , Christian Drosten†, Silvia Bino‡, Εvangelia Papadimitriou*, Marcus Panning†, Enkelejda Velo‡, Majlinda Kota‡, Arjan Harxhi§, and Antonis Antoniadis*
Author affiliations: *Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece; †Berhard Nocht Institute for Tropical Medicine, Hamburg, Germany; ‡Institute of Public Health, Tirana, Albania; §University Hospital, Tirana, Albania;

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Table

Epidemiologic, molecular, and clinical data for 12 Albanian patients with suspected Crimean-Congo hemorrhagic fever, 2003–2006*

Patient
Day of illness
In hospital
Outcome
Real-time RT-PCR, geqs/reaction
IFA
TNF-α, pg/mL
sTNF-R, ng/mL
IL-6, pg/mL
IL-10, pg/mL
Leukocytes, × 109/L
Platelets, × 109/L
Group A
primary
23/03 6 Yes D 28,990,000 + 68.5 14.0 109.7 388.3 1,700 36,200
82/03 5 Yes R 450 + N N 17.0 23.9 2,300 96,830
154/04 18 Yes R 33 + ND ND ND ND 15,000 71,400
178/04 4 Yes R 7,271,000 + ND ND ND 4,100 62,550
252/06
2
Yes
R
4049

ND
ND
ND
ND
3,700
117,900
Group A
secondary
24b/03 9 Yes R 166 + 1,444.8 N 114.2 N 4,800 63,800
25b/03 9 Yes R 40 + N N 10.3 N 3,800 63,000
50/03 3 No R 240 N N N 43.4 ND ND
52/03 3 No R 18 N N N 9.9 ND ND
56/03 5 No R 62 + N N 26.1 N ND ND
34/03
5
Yes
R
46

N
8.9
N
N
8,000
102,000
Group B
secondary
40/03 7 No R 14 + N N N 23.1 ND ND

*RT-PCR, reverse transcription–PCR; geqs, genome equivalents; IFA, immunofluorescent assay; TNF-α, tumor necrosis factor-α; sTNF
R, soluble TNF-α receptor; IL-6, interleukin-6; D, died; +, positive; R, recovered; N, normal value; ND, not done; –, negative.

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