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Volume 13, Number 6—June 2007

Research

Strategies to Reduce Person-to-Person Transmission during Widespread Escherichia coli O157:H7 Outbreak

Edmund Y.W. Seto*, Jeffrey A. Soller†Comments to Author , and John M. Colford*
Author affiliations: *University of California at Berkeley School of Public Health, Berkeley, California, USA; †Soller Environmental/Eisenberg, Olivieri, & Associates, Berkeley, California, USA

Main Article

Table

Disease transmission model parameter values

Description Model parameter Values used for base analysis (range*)
Mean duration of incubation† ζ 5 d (2–8 d)
Probability of symptomatic response Psym 0.28
Mean duration of infection* σ, δ 16 d (4–29 d)
Mean duration of protection from infection* γ 56 d (35–77 d)
Hypergeometric dose response relation α, β 0.08, 1.44
Nonoutbreak annual disease incidence in United States 73,480 cases
Population N 275 million persons
Proportion of cases due to person-to-person transmission k 0.12–0.75
Timing of interventions 0,1, and 2 weeks after press release
Effectiveness of Interventions R(t) 1%–25%

*Range used for uncertainty analysis.
†Inverse is used as a rate in the model (i.e., units of days–1).

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