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Volume 13, Number 8—August 2007

Research

Risk Factors for Colonization with Extended-Spectrum β-Lactamase–producing Bacteria and Intensive Care Unit Admission

Anthony D. Harris*†Comments to Author , Jessina C. McGregor*, Judith A. Johnson*†, Sandra M. Strauss*, Anita C. Moore*, Harold C. Standiford‡, Joan N. Hebden‡, and J. Glenn Morris*
Author affiliations: *University of Maryland, Baltimore, Maryland, USA; †Veterans Affairs Maryland Health Care System, Baltimore, Maryland, USA; ‡University of Maryland Medical Center, Baltimore, Maryland, USA;

Main Article

Table 1

Potential predictors of colonization by an ESBL-producing bacterium on ICU admission*

Potential predictorNo. ESBL colonized
(n = 117)No. not ESBL colonized
(n = 5,092)p value†
Age, y (median, IQR)62 (49–71)56 (45–67)<0.01
CDS (median, IQR)8 (5–10)8 (5–10)0.20
CDS-ID (median, IQR)3.21 (1.83–4.78)2.83 (1.83–3.40)<0.01
Sex, female, no. (%)59 (50)2,311 (45)0.30
Antimicrobial drug exposures, no. (%)‡
Quinolone18 (15)617 (12)0.32
1st-generation cephalosporin9 (8)559 (11)0.30
3rd-generation cephalosporin7 (6)293 (6)0.84
Vancomycin34 (29)616 (12)<0.01
Aminoglycoside11 (9)366 (7)0.36
Piperacillin-tazobactam50 (43)1,090 (21)<0.01
Cefepime9 (8)161 (3)0.01
Imipenem11 (9)224 (4)0.02

*ESBL, extended-spectrum β-lactamase; ICU, intensive care unit; IQR, interquartile range; CDS, Chronic Disease Score; CDS-ID, infectious disease–specific CDS.
†Fisher exact test for dichotomous predictors and Wilcoxon test for continuous predictors.
‡Antimicrobial drug exposures that occurred during the index hospital admission but before ICU admission.

Main Article

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