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Volume 13, Number 8—August 2007

Research

Source of Variant Creutzfeldt-Jakob Disease outside United Kingdom

Pascual Sanchez-Juan*†, Simon N. Cousens‡, Robert G. Will§, and Cornelia M. van Duijn*Comments to Author 
Author affiliations: *Erasmus Medical Center, Rotterdam, the Netherlands; †University Hospital “Marqués de Valdecilla,” Santander, Spain; ‡London School of Hygiene and Tropical Medicine, London, UK; §Western General Hospital, Edinburgh, UK

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Table 2

Results of nonparametric correlation analyses between number of variant Creutzfeldt-Jakob disease (vCJD) cases and the 3 studied exposure sources*

Countries and vCJD case-patients included in analysis Exposure
Indigenous BSE cases 
(CI, p value) Live bovines imported 
from UK, 1980–1990 
(CI, p value)† Carcass meat imported 
from UK, 1980–1996 
(CI, p value)†
All EU network countries
Patients likely to have been 
 infected in UK excluded rs = 0.70 
(CI 0.37–0.87, p = 0.001) rs = 0.73 
(0.42–0.89, p<0.001) rs = 0.75 
(0.45–0.89, p<0.001)
Patients likely to have been 
 infected in UK included
rs = 0.60 
(0.21–0.82, p = 0.005)
rs = 0.63
(0.26–0.84, p = 0.003)
rs = 0.64 
(0.27–0.84, p = 0.003)
All EU network countries plus Japan and Saudi Arabia
Patients likely to have been 
 infected in UK excluded rs = 0.55
(0.17–0.79, p = 0.008) rs = 0.65 
(0.31–0.84, p = 0.001) rs = 0.73 
(0.45–0.88, p<0.001)
Patients likely to have been 
 infected in UK included
rs = 0.51
(0.11–0.77, p = 0.02)
rs = 0.52 
(0.13–0.77, p = 0.01)
rs = 0.57 
(0.19–0.80, p = 0.006)
All countries except France
Patients likely to have been
 infected in UK excluded rs = 0.48
(0.06–0.75, p = 0.03) rs = 0.60 
(0.23–0.81, p = 0.005) rs = 0.68 
(0.36–0.86, p = 0.001)
Patients likely to have been 
 infected in UK included rs = 0.44
(0.01–0.73, p = 0.05) rs = 0.44 
(0.01–0.73, p = 0.05) rs = 0.49 
(0.08–0.76, p = 0.02)

*BSE, bovine spongiform encephalopathy; UK, United Kingdom; EU, European Union; CI, confidence interval; rs Spearman rank correlation coefficient.
†Weighted by the temporal distribution of the export in relation to the size of the BSE epizootic in the UK.

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