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Volume 14, Number 10—October 2008

Perspective

Rise and Persistence of Global M1T1 Clone of Streptococcus pyogenes

Ramy K. AzizComments to Author  and Malak Kotb
Author affiliations: Cairo University, Cairo, Egypt (R.K. Aziz); VA Medical Center, Memphis, Tennessee, USA (R.K. Aziz, M. Kotb)University of Tennessee Health Science Center, Memphis (M. Kotb); University of Cincinnati, Cincinnati, Ohio, USA (M. Kotb);

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Table

Genomic differences between M1T1 and M1 SF370*

Difference M1T1 SF370
Prophages or prophage remnants SPhinX (speA2), MemPhiS (mf3/mf4), PhiRamid (sda1) 370.1 (mf2, speC), 370.2 (speH, speI), 370.3 (mf3), 370.4 (phage remnant)
Superantigen genes speA2, speG, speJ, smeZ1, speC, speG, speH, speI, speJ, smeZ1
Streptodornases mf/spd, mf3/spd OR mf4/spd4, sda1 mf/spd, mf2, mf3/spd3
Other Insertion sequence (IS1548), SNP in the SLO/NADGH region

*SNP, single nucleotide polymorphism; SLO, streptolysin O; NADGH, nicotinamide glycohydrolase. Toxin gene names in boldface designate genes that are unique to either strain.

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