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Volume 14, Number 10—October 2008

Research

Prophylaxis after Exposure to Coxiella burnetii

Claire E. MoodieComments to Author , Herbert A. Thompson, Martin I. Meltzer, and David L. Swerdlow
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA;

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Figure 1

Decision tree for a general population of 100,000 based on an assumption of an aerosolized, point source, overt attack with Coxiella burnetii (postexposure prophylaxis [PEP] with 100 mg doxycycline 2×/d for 5 d, assuming 82% drug efficacy and 100% exposure). PEP-related adverse events are not included in this figure. The probability of each individual event occurring is provided in the decision tree under the respective event title (i.e., 1.00 for Exposure). Some events list a range of probabili

Figure 1. Decision tree for a general population of 100,000 based on an assumption of an aerosolized, point source, overt attack with Coxiella burnetii (postexposure prophylaxis [PEP] with 100 mg doxycycline 2×/d for 5 d, assuming 82% drug efficacy and 100% exposure). PEP-related adverse events are not included in this figure. The probability of each individual event occurring is provided in the decision tree under the respective event title (i.e., 1.00 for Exposure). Some events list a range of probabilities with the specific probability for this scenario in parentheses (i.e., “0.82–0.965 (0.82)” for “PEP No illness”). The number of persons with each respective outcome is listed on the right side of the tree. A summary of outcomes (total illness, severe illness and death) and the percentage of the population with such an outcome are provided in the table below the PEP and “No PEP” trees. We defined total illness as all acute illness, severe illness, and Q fever–related deaths. Severe illness was defined as hospitalization during acute infection, chronic illness, Q fever fatigue syndrome (QFS), or death. This description also applies to Figures 2 and 3.

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