Volume 14, Number 10—October 2008
Research
Prophylaxis after Exposure to Coxiella burnetii
Claire E. Moodie
, Herbert A. Thompson, Martin I. Meltzer, and David L. Swerdlow
, Herbert A. Thompson, Martin I. Meltzer, and David L. SwerdlowTable 1
Input values used in the primary and secondary analyses of PEP efficacy*
| Variable | Primary analysis (sensitivity analysis) | Sensitivity analyses |
References | |
|---|---|---|---|---|
| Less virulent | More virulent | |||
| Exposure | (0.10, 0.25, 0.50, 1.00) | NA | NA | NA |
| Efficacy of doxycycline PEP (8–12 d postexposure) | 0.82 (0.82–0.965) | 0.965 | 0.40 | (22,23) |
| Efficacy of trimethoprim-sulfamethoxazole PEP (8–12 d postexposure) | 0.82 (0.40–0.965) | 0.965 | 0.40 | (21,24,25) |
| Asymptomatic infection w/o PEP (all groups) | 0.50 | 0.65 | 0.40 | (1,3,5,7,8,26) |
| Full recovery after acute (gp) | 0.74 | Residual (0.934) | Residual (0.576) | (7–9) |
| Full recovery after acute illness (hr) | 0.28 | Residual (0.739) | Residual (0.076) | (7–9) |
| Full recovery after acute illness (pw) | 0.08 | Residual (0.57) | Residual (0.02) | (7–9) |
| Probability of hospitalization and recovery given acute illness (gp) | 0.04 | 0.01 | 0.05 | (5,7,27) |
| Probability of hospitalization and recovery given acute illness (hr) | 0.01 | 0.01 | 0.05 | (5,7) |
| Probability of hospitalization and recovery given acute illness (pw) | 0.01 | 0.01 | 0.02 | (5,7) |
| Q fever fatigue syndrome (gp) | 0.20 | 0.05 | 0.30 | (1,10,16,28–30) |
| Q fever fatigue syndrome (hr) | 0.30 | 0.05 | 0.20 | (1,10,16,28–30) |
| Q fever fatigue syndrome (pw) | 0.03 | Residual (0.03) | Residual (0.04) | (1,10,16,17,28–30) |
| Death from acute illness (gp) | 0.01 | 0.001 | 0.024 | (7,9–11) |
| Death from acute illness (hr and pw) | 0.02 | 0.001 | 0.024 | (7,9–11) |
| Chronic disease (gp) | 0.01 | 0.005 | 0.05 | (8,11,12,26,31) |
| Chronic disease (hr) | 0.39 | 0.20 | 0.65 | (13,14,31) |
| Chronic disease (pw) | 0.86 | 0.39 | 0.90 | (17) |
| Endocarditis (all groups) | 0.65 | 0.60 | 0.90 | (1,7,8) |
| Death from endocarditis (all groups) | 0.10 | 0.05 | 0.60 | (1,3,7,8,11,15,32) |
| Death from other chronic diseases (all groups) | 0.30 | 0.05 | 0.60 | (9) |
| Abortion or neonatal death | 0.38 | 0.25 | 0.56 | (8,14 ,17,21) |
| Premature birth/low birth weight baby | 0.33 | 0.25 | 0.28 | (8,14,17,21) |
| Healthy, unaffected baby | 0.29 | 0.50 | 0.16 | (8,14,17,21) |
*PEP, postexposure prophylaxis; NA, not applicable; gp, general population; hr, high-risk; pw, pregnant women. See online Appendix Table 1 for a detailed explanation of how the primary input values were selected.
