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Volume 14, Number 2—February 2008

Research

Unexpected Occurrence of Plasmid-Mediated Quinolone Resistance Determinants in Environmental Aeromonas spp.

Vincent Cattoir*†‡, Laurent Poirel*†, Camille Aubert*†, Claude-James Soussy‡, and Patrice Nordmann*†Comments to Author 
Author affiliations: *Institut Nationale de la Santé et de la Recherche Médicale Unité 914, Le Kremlin-Bicêtre, France; †Hôpital de Bicêtre, Le Kremlin-Bicêtre; ‡Université Paris XII, Créteil, France;

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Table

MICs (mg/L) of quinolones and fluoroquinolones for Aeromonas punctata 37, A. media 42, and Escherichia coli TOP10 harboring natural plasmids p37 and p42*

Antimicrobial agent A. punctata 37 A. media 42 E. coli TOP10 with plasmids
E. coli TOP10
p37 p42
Nalidixic acid >256 >256 4 4 1
Norfloxacin 16 64 1 1 0.03
Ofloxacin 8 >32 0.5 0.5 0.01
Ciprofloxacin 4 >32 0.12 0.25 <0.01
Moxifloxacin 4 32 0.25 0.25 <0.01
Sparfloxacin 16 >32 0.25 0.25 <0.01
Enrofloxacin 4 >32 0.5 0.5 <0.01

*Each expressing the plasmid-mediated quinolone determinant QnrS2 from A. punctata 37 and A. media 42, respectively, and E. coli reference strain TOP10.

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