Emerging Infectious Disease ISSN: 1080-6059

Potential Use of Antiviral Agents in Polio Eradication

Armando M. De Palma*, Gerhard Pürstinger†, Eva Wimmer†, Amy K. Patick‡, Koen Andries§, Bart Rombaut¶, Erik De Clercq*, and Johan Neyts*

Author affiliations: *University of Leuven, Leuven, Belgium; †University of Innsbruck, Innsbruck, Austria; ‡Pfizer Global Research and Development, San Diego, California, USA; §J&J Pharmaceutical Research and Development, Beerse, Belgium; ¶Vrije Universiteit Brussel, Brussels, Belgium;

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Figure 1

Structural formulas of selected poliovirus inhibitors. A) Capscid binders; B) protease inhibitors; C) 3A inhibitor; D) nucleoside analogs; E) 2C inhibitors; F) unknown target. HBB, 2-(α-hydroxybenzyl)-benzimidazole.

Figure 1. Structural formulas of selected poliovirus inhibitors. A) Capscid binders; B) protease inhibitors; C) 3A inhibitor; D) nucleoside analogs; E) 2C inhibitors; F) unknown target. HBB, 2-(α-hydroxybenzyl)-benzimidazole.

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