Emerging Infectious Disease ISSN: 1080-6059

Potential Use of Antiviral Agents in Polio Eradication

Armando M. De Palma*, Gerhard Pürstinger†, Eva Wimmer†, Amy K. Patick‡, Koen Andries§, Bart Rombaut¶, Erik De Clercq*, and Johan Neyts*

Author affiliations: *University of Leuven, Leuven, Belgium; †University of Innsbruck, Innsbruck, Austria; ‡Pfizer Global Research and Development, San Diego, California, USA; §J&J Pharmaceutical Research and Development, Beerse, Belgium; ¶Vrije Universiteit Brussel, Brussels, Belgium;

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Figure 2

Effect of selected inhibitors on production of infectious poliovirus 1 Sabin in HeLa cell cultures. Supernatants collected from 3 independent experiments were titrated for infectious virus content, and 50% cell culture infective dose (CCID50) values were calculated as described by Reed and Muench (34). A) Ruprintrivir; B) enviroxime; C) MRL-1237; D) pleconaril.

Figure 2. Effect of selected inhibitors on production of infectious poliovirus 1 Sabin in HeLa cell cultures. Supernatants collected from 3 independent experiments were titrated for infectious virus content, and 50% cell culture infective dose (CCID₅₀) values were calculated as described by Reed and Muench (34). A) Ruprintrivir; B) enviroxime; C) MRL-1237; D) pleconaril.

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