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Volume 14, Number 4—April 2008

CME ACTIVITY

β-Herpesviruses in Febrile Children with Cancer

Stephanie Yee-Guardino*, Kate Gowans*, Belinda Yen-Lieberman†, Pamela Berk†, Debra Kohn†, Fu-Zhang Wang†1, Lara Danziger-Isakov*†, Camille Sabella*†, Sarah Worley†, Philip E. Pellett†2Comments to Author , and Johanna Goldfarb*†
Author affiliations: *Cleveland Clinic Children’s Hospital, Cleveland, Ohio, USA; †Cleveland Clinic, Cleveland, Ohio, USA; 1Current affiliation: University of North Carolina, Chapel Hill, North Carolina, USA; 2Current affiliation: Wayne State University School of Medicine, Detroit, Michigan, USA;

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Table 2

Detection of β-herpesviruses in cancer patients and solid-organ transplant recipients*

Characteristic Cancer patients, no. positive/no. tested (%)
Transplant patients (n = 9), 
no. positive/no. tested (%)
Leukemia (n = 9) Solid tumor (n = 20)
CMV PCR
  Whole blood 1/6 (17) 0/5 3/7 (43)
  PBMC 1/7 (14) 0/16 2/8 (25)
  Plasma 0/9 0/20 2/9 (22)
  All tests
1/9 (11)
0/20 (0)
3/9 (33)
HHV-6 PCR
  Whole blood 2/6 (33) 0/5 2/7 (29)
  PBMC 1/7 (14) 1/16 (6) 3/8 (38)
  Plasma 0/9 0/19 1/9 (11)
  Lymphocyte culture 1/8 (13) 0/16 0/9
  All tests
3/9 (33)
1/20 (5)
3/9 (33)
HHV-7 PCR
  Whole blood 0/6 0/5 0/7
  PBMC 0/7 0/16 0/8
  Plasma 0/9 0/20 0/9
  All tests 0/9 0/20 0/9

*Data are not shown for study participant 23, a patient with lymphoma who did not have β-herpesviruses detected in whole blood, PBMC, or plasma. CMV, cytomegalovirus; PBMC, peripheral blood mononuclear cells; HHV-6, human herpesvirus 6.

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1Current affiliation: University of North Carolina, Chapel Hill, North Carolina, USA

2Current affiliation: Wayne State University School of Medicine, Detroit, Michigan, USA

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