Emerging Infectious Disease ISSN: 1080-6059

Persistent Human Metapneumovirus Infection in Immunocompromised Child

Yacine Abed*† and Guy Boivin*†

Author affiliations: *Centre Hospitalier Universitaire de Québec, Quebec City, Quebec, Canada; †Infectious Disease Research Centre, Quebec City, Quebec, Canada

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Figure

A) Phylogenetic analysis of human metapneumovirus (hMPV) strains isolated during an 11-month period based on nucleotide sequences of the G gene. Multiple nucleotide sequence alignments were performed by using the ClustalW program (www.molecularevolution.org/cdc/software/clustalw); a phylogenetic tree was constructed with MEGA 3.1 software (www.megasoftware.net) by using the neighbor-joining algorithm with Kimura-2 parameters. The analysis included the following hMPV reference strains: Can98/75 (GenBank accession no. AY485245), NL1/94 (AY304362), NL1/99 (AY304361), NL1/00 (AF371337), NL17/00 (AY304360), and Can97/83 (AY485253). Scale bar indicates 1 substitution for every 10 nucleic acid residues. Boldface indicates reference isolates. B) Comparison of the partial amino acid sequences (residues 26–236) of the G protein of hMPV isolates recovered during an 11-month period from an immunocompromised child. Asterisks denote identical residues; shaded boxes highlight different amino acids between the hMPV variant of November 4, 2005, and the subsequent variants from January 20, 2006, to October 4, 2006.

Figure. A) Phylogenetic analysis of human metapneumovirus (hMPV) strains isolated during an 11-month period based on nucleotide sequences of the G gene. Multiple nucleotide sequence alignments were performed by using the ClustalW program (www.molecularevolution.org/cdc/software/clustalw); a phylogenetic tree was constructed with MEGA 3.1 software (www.megasoftware.net) by using the neighbor-joining algorithm with Kimura-2 parameters. The analysis included the following hMPV reference strains: Can98/75 (GenBank accession no. AY485245), NL1/94 (AY304362), NL1/99 (AY304361), NL1/00 (AF371337), NL17/00 (AY304360), and Can97/83 (AY485253). Scale bar indicates 1 substitution for every 10 nucleic acid residues. Boldface indicates reference isolates. B) Comparison of the partial amino acid sequences (residues 26–236) of the G protein of hMPV isolates recovered during an 11-month period from an immunocompromised child. Asterisks denote identical residues; shaded boxes highlight different amino acids between the hMPV variant of November 4, 2005, and the subsequent variants from January 20, 2006, to October 4, 2006.

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