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Volume 14, Number 6—June 2008

Letter

Vibrio cholerae O1 Hybrid El Tor Strains, Asia and Africa

Ashrafus Safa*, Jinath Sultana*, Phung Dac Cam†, James C. Mwansa‡, and Richard Y.C. Kong*Comments to Author 
Author affiliations: *City University of Hong Kong, Hong Kong Special Administrative Region, People’s Republic of China; †National Institute of Hygiene and Epidemiology, Hanoi, Vietnam; ‡University Teaching Hospital, Lusaka, Zambia;

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Table

Phenotypic and genotypic traits of Vibrio cholerae O1 clinical strains isolated from Asia and Africa, 1991–2004*

Test strain origin (no. examined) or reference strain ID Year(s) of isolation rfbO1 Phenotypic tests
PCR amplicons
Cholera toxin type† (no. strains)
CCA Polymyxin B (50 U) Voges-Proskauer tcpA
(El Tor) tcpA (classical) rtxC
Japan (6) 1991–1997 + + Resistant + + + Classical (5), 
El Tor (1)
Hong Kong (18) 1998–2000 + + Resistant + + + Classical (11), 
El Tor (7)
Zambia (8) 1996–2004 + + Resistant + + + Classical (5), 
El Tor (3)
China (3) 1999 + + Resistant + + + Classical (3), 
El Tor (0)
Sri Lanka (1) 1998 + + Resistant + + + Classical (1), 
El Tor (0)
Vietnam (5) 1994–2002 + + Resistant + + + Classical (5), 
El Tor (0)
Classical 569B 1948 + Sensitive + Classical
El Tor N16961 1971 + + Resistant + + + El Tor

*rfbO1, O-antigen biosynthesis genes; CCA, chicken cell agglutination; tcp, toxin-coregulated pilus; rtx, repeat in toxin.
†Based on ctxB sequence. GenBank accession nos. for the ctxB sequences are EU156448–EU156488.

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