Volume 14, Number 7—July 2008
Research
Determinants of Cluster Size in Large, Population-Based Molecular Epidemiology Study of Tuberculosis, Northern Malawi
Judith R. Glynn*
, Amelia C. Crampin*†, Hamidou Traore*, Steve Chaguluka†, Donex T. Mwafulirwa†, Saad Alghamdi*, Bagrey M.M. Ngwira†, Malcolm D. Yates‡, Francis D. Drobniewski‡, and Paul E.M. Fine*
, Amelia C. Crampin*†, Hamidou Traore*, Steve Chaguluka†, Donex T. Mwafulirwa†, Saad Alghamdi*, Bagrey M.M. Ngwira†, Malcolm D. Yates‡, Francis D. Drobniewski‡, and Paul E.M. Fine*Table 3
Proportion of all tuberculosis cases caused by each of the RFLP-defined large cluster strains over time, Malawi*
| Strain | No. patients | Tuberculosis cases caused by each strain, % (no.) |
p value | |||
|---|---|---|---|---|---|---|
| 1995–1997 | 1998–1999 | 2000–2001 | 2002–2003 | |||
| Kps10 | 18 | 2.3 (6) | 0.9 (3) | 1.7 (5) | 2.8 (4) | 0.4 |
| Kps12 | 34 | 1.5 (4) | 3.9 (13) | 4.9 (14) | 2.1 (3) | 0.1 |
| Kps20 | 15 | 1.9 (5) | 0.9 (3) | 1.7 (5) | 1.4 (2) | 0.7 |
| Kps21 | 15 | 0.8 (2) | 2.1 (7) | 2.1 (6) | 0.0 (0) | 0.2 |
| Kps41 | 37 | 4.2 (11) | 3.0 (10) | 4.5 (13) | 2.1 (3) | 0.5 |
| Kps44 | 29 | 3.8 (10) | 3.3 (11) | 1.4 (4) | 2.8 (4) | 0.3 |
| Kps64 | 16 | 0.4 (1) | 1.5 (5) | 2.8 (8) | 1.4 (2) | 0.1 |
| Kps97 | 15 | 0.8 (2) | 2.4 (8) | 1.0 (3) | 0.7 (1) | 0.3 |
| Kps104 | 16 | 1.5 (4) | 0.9 (3) | 2.1 (6) | 2.1 (3) | 0.6 |
| Kps121 | 27 | 4.2 (11) | 2.7 (9) | 2.1 (6) | 0.7 (1) | 0.03 (trend) |
*RFLP, restriction fragment length polymorphism.
