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Volume 14, Number 7—July 2008

Research

Determinants of Cluster Size in Large, Population-Based Molecular Epidemiology Study of Tuberculosis, Northern Malawi

Judith R. Glynn*Comments to Author , Amelia C. Crampin*†, Hamidou Traore*, Steve Chaguluka†, Donex T. Mwafulirwa†, Saad Alghamdi*, Bagrey M.M. Ngwira†, Malcolm D. Yates‡, Francis D. Drobniewski‡, and Paul E.M. Fine*
Author affiliations: *London School of Hygiene and Tropical Medicine, London, UK; †Karonga Prevention Study, Chilumba, Malawi; ‡Health Protection Agency, London;

Main Article

Table 3

Proportion of all tuberculosis cases caused by each of the RFLP-defined large cluster strains over time, Malawi*

Strain No. patients Tuberculosis cases caused by each strain, % (no.)
p value
1995–1997 1998–1999 2000–2001 2002–2003
Kps10 18 2.3 (6) 0.9 (3) 1.7 (5) 2.8 (4) 0.4
Kps12 34 1.5 (4) 3.9 (13) 4.9 (14) 2.1 (3) 0.1
Kps20 15 1.9 (5) 0.9 (3) 1.7 (5) 1.4 (2) 0.7
Kps21 15 0.8 (2) 2.1 (7) 2.1 (6) 0.0 (0) 0.2
Kps41 37 4.2 (11) 3.0 (10) 4.5 (13) 2.1 (3) 0.5
Kps44 29 3.8 (10) 3.3 (11) 1.4 (4) 2.8 (4) 0.3
Kps64 16 0.4 (1) 1.5 (5) 2.8 (8) 1.4 (2) 0.1
Kps97 15 0.8 (2) 2.4 (8) 1.0 (3) 0.7 (1) 0.3
Kps104 16 1.5 (4) 0.9 (3) 2.1 (6) 2.1 (3) 0.6
Kps121 27 4.2 (11) 2.7 (9) 2.1 (6) 0.7 (1) 0.03 (trend)

*RFLP, restriction fragment length polymorphism.

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