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Volume 14, Number 7—July 2008


Importation of West Nile Virus Infection from Nicaragua to Spain

Begoña Monge Maillo*, Rogelio López-Vélez*Comments to Author , Francesca Norman*, Fernando de Ory†, María Paz Sanchez-Seco†, and Cesare Giovanni Fedele†
Author affiliations: *Ramon y Cajal Hospital, Madrid, Spain; †Instituto de Salud Carlos III, Madrid;

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Serologic results for antibodies to West Nile virus (WNV), dengue virus (DV), and tick-borne encephalitis virus (TBEV)*

d after onset WNV
IgG† IgG‡ IT-IgG§ IgM† Ab‡ IT Ab¶ IgG† IgM† IgG† IgM†
S1/13 3.5 65,000 3.54 3.6 256 7.0 4.8 0.3 59.5 0.1
CSF/13 4,000 Pos# 32
S2/160 3.2 16,000 0.8 64 4.5 0.2 27 0.1

*PRNT, plaque reduction neutralization assay; Ig, immunoglobulin; Ab, antibodies; IT, intrathecal; S1, first serum sample, obtained 13 days after onset of symptoms; CSF, cerebrospinal fluid; Pos, positive; S2, second serum sample, obtained 160 days after onset of symptoms.
†Results expressed as the ratio of sample absorbance to cutoff value (positive >1.0).
§IT production of WNV IgG (ELISA).
¶IT production of WNV antibodies (PRNT).
#CSF tested diluted 1:2.

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