Volume 14, Number 7—July 2008
Online Report
Materials Available Online Only
Toward a Unified Nomenclature System for Highly Pathogenic Avian Influenza Virus (H5N1)
Table 2
Clade descriptions with isolation period, source, and geographic location*
| Clade | Year | Geographic location | Isolation source | Description and strain name |
|---|---|---|---|---|
| 0 |
1996–2002 |
PRC, Hong Kong |
Avian/human |
Early progenitors of H5N1; HK/PRC 1997 avian influenza outbreak
Gs/Guangdong/1/96 |
| 3 |
2000–2001 |
PRC, Hong Kong, Vietnam |
Avian |
Ck/Hong Kong/YU562/2001 |
| 4 | 2002/2003 | PRC, Hong Kong | Avian | Gs/Guiyang/337/2006 |
| 2005/2006 |
Guiyang, PRC |
Avian |
Described as Guiyang 1 (5) |
|
| 5 | 2000–2003 | PRC, Vietnam | Avian | Gs/Guangxi/914/2004 |
| 2004 |
Guangxi, PRC |
Avian |
||
| 6 |
2002/2004 |
PRC |
Avian |
Ck/Hunan/01/2004 |
| 7 | 2002/2004 | PRC | Avian/human | Human case from Beijing in 2003 |
| 2005/2006 |
Yunnan, Hubei, and Shanxi, PRC |
Avian |
Described as Yunnan 2 (5)
Ck/Shanxi/2/2006 |
|
| 8 |
2001–2004 |
Hong Kong, PRC |
Avian |
Ck/Hong Kong/YU777/2002 |
| 9 |
2003–2005 |
PRC |
Avian |
Dk/Guangxi/2775/2005 |
| 1 | 2002/2003 | Hong Kong, PRC | Avian/human | Described as Guangdong (3) |
| Vietnam, Cambodia,
Thailand, Laos, Malaysia |
Avian/human |
Spread of H5N1 to southeast Asia;
described as Vietnam/Thailand/Malaysia (3)
Vietnam/1203/2004 |
||
| 2.1.1 |
2003–2005 |
Eastern Indonesia |
Avian |
Described as Indonesia (ref 3)
Ck/Indonesia/BL/2003 |
| 2.1.2 |
2005–2006 |
Western Indonesia |
Avian/human |
Primarily avian with human cluster from Medan; described as Indonesia (3)
Indonesia/538H/2006 |
| 2.1.3 |
2004–2007 |
Eastern and western
Indonesia |
Avian/human |
Described as Indonesia (3)
Indonesia/5/2005 |
| 2.2 | 2005 | Qinghai Lake, Jiangxi, PRC | Avian | Progenitors from Qinghai Lake outbreak; described as Qinghai-like (5) |
| 2005–2007 |
Mongolia, Europe,
Middle East, Africa |
Avian/human |
Long-distance spread of H5N1; described as EMA clade (4)
BHGs/Qinghai/1A/2005 |
|
| 2.3.1 |
2003–2005 |
Hunan and Guangdong, PRC |
Avian |
Described as Hunan (3)
Dk/Hunan/303/2004 |
| 2.3.2 | 2004–2006 | Hong Kong, southern PRC | Avian | Described as Mixed/Vietnam 2 (3,5) |
| 2005 |
Vietnam |
Avian |
Described as Mixed/Vietnam 2 (3,5)
Ck/Guangxi/2461/2004 |
|
| 2.3.3 | 2004 | Hunan, PRC | Avian | Ck/Guiyang/3055/2005 |
| 2005 |
Guiyang, PRC |
Avian |
Described as Guiyang 2 (5) |
|
| 2.3.4 |
2005–2006 |
Hong Kong, PRC, Thailand, Laos, Malaysia |
Avian/human |
Described as Fujian-like (5)
Dk/Fujian/1734/2005 |
| 2.4 |
2002–2005 |
PRC (predominantly
Yunnan and Guangxi) |
Avian |
Described as Yunnan (3)
Ck/Yunnan/115/2004 |
| 2.5 | 2003/2004 | PRC, Korea, Japan | Avian | Spread of H5N1 to east Asian countries |
| 2006 | Shantou, PRC | Avian | Described as Guangdong/2006 (5) Ck/Korea/ES/2003 |
*PRC, People’s Republic of China; BHGs, bar-headed goose; Ck, chicken; Dk, duck; Gs, goose. Strain name in boldface represents the prototype virus for that clade.
1The working group was established by request of the World Health Organization’s Global Influenza Programme, Department of Epidemic and Pandemic Alert and Response (WHO, GIP, EPR), the World Organisation for Animal Health (OIE), and the Food and Agriculture Organization (FAO). It consisted of the following members: Ruben O. Donis, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA (co-chair); Gavin J.D. Smith, University of Hong Kong, Hong Kong Special Administrative Region, People’s Republic of China (co-chair); Michael L. Perdue, WHO, GIP, EPR, Geneva, Switzerland2 (coordinator); Ian H. Brown, Veterinary Laboratories Agency, Addlestone, UK; Hualan Chen, Harbin Veterinary Research Institute, Chinese Academy of Agriculture Sciences CAAS, Harbin, People’s Republic of China; Ron A.M. Fouchier, Erasmus University, Rotterdam, the Netherlands; Yoshihiro Kawaoka, University of Wisconsin-Madison, Madison, Wisconsin, USA, and Institute of Medical Science, University of Tokyo, Tokyo, Japan; John Mackenzie, Curtin University of Technology, Perth, Western Australia, Australia; and Yuelong Shu, China Centers for Disease Control, Bejing, People’s Republic of China. In addition, the following persons made substantial contributions: Ilaria Capua, Instituto Zooprofilattico Sperimentale delle Venezie, Padova, Italy; Nancy Cox, Todd Davis, Rebecca Garten, and Catherine Smith, CDC; Yi Guan and Dhanasekaran Vijaykrishna, University of Hong Kong; Elizabeth Mumford, WHO, GIP, EPR; and Colin A. Russell and Derek Smith, University of Cambridge, Cambridge, UK.
2Current affiliation: US Department of Health and Human Services, Washington, DC, USA.


