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Volume 14, Number 9—September 2008

Dispatch

Crack Cocaine and Infectious Tuberculosis

Alistair StoryComments to Author , Graham Bothamley, and Andrew Hayward
Author affiliations: Health Protection Agency, London, UK (A. Story); Homerton Hospitals National Health Service Foundation Trust, London (G. Bothamley); University College London Centre for Infectious Disease Epidemiology, London (A. Hayward)

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Table 2

Multivariate analysis of risk factors for smear-positive disease on diagnosis among drug-using and non–drug-using patients with pulmonary TB in London, UK, 2003–2004*

Variable OR 95% CI p value
Not a hard-drug user Baseline
Hard-drug user (not known to use crack cocaine) 1.87 1.19–2.95 0.007
Crack cocaine user
6.59
1.78–24.31
0.005
Age, y
0–14 0.10 0.08–0.56 0.002
15–29 1.10 0.81–1.48 0.55
30–59 Baseline
>60
0.69
0.45–1.14
0.14
Ethnicity
South Asian Baseline
Black African 1.75 0.96–1.95 0.08
White 1.51 0.99–2.31 0.053
Black Caribbean 2.70 1.34–5.43 0.005
Other ethnicity
1.61
0.91–2.85
0.101
No drug resistance Baseline
INH (not outbreak strain) 1.23 0.72–2.11 0.441
INH (outbreak strain) 0.96 0.37–2.50 0.929
MDR 2.90 1.44–5.78 0.003
Sought treatment at ED 3.33 2.20–4.82 <0.001

*OR, odds ratio; CI, confidence interval; INH, isoniazid resistant; MDR, multidrug-resistant; ED, emergency department.

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