Volume 14, Number 9—September 2008
Dispatch
Crack Cocaine and Infectious Tuberculosis
Alistair Story
, Graham Bothamley, and Andrew Hayward
, Graham Bothamley, and Andrew HaywardTable 2
Multivariate analysis of risk factors for smear-positive disease on diagnosis among drug-using and non–drug-using patients with pulmonary TB in London, UK, 2003–2004*
| Variable | OR | 95% CI | p value |
|---|---|---|---|
| Not a hard-drug user | Baseline | ||
| Hard-drug user (not known to use crack cocaine) | 1.87 | 1.19–2.95 | 0.007 |
| Crack cocaine user |
6.59 |
1.78–24.31 |
0.005 |
| Age, y | |||
| 0–14 | 0.10 | 0.08–0.56 | 0.002 |
| 15–29 | 1.10 | 0.81–1.48 | 0.55 |
| 30–59 | Baseline | ||
| >60 |
0.69 |
0.45–1.14 |
0.14 |
| Ethnicity | |||
| South Asian | Baseline | ||
| Black African | 1.75 | 0.96–1.95 | 0.08 |
| White | 1.51 | 0.99–2.31 | 0.053 |
| Black Caribbean | 2.70 | 1.34–5.43 | 0.005 |
| Other ethnicity |
1.61 |
0.91–2.85 |
0.101 |
| No drug resistance | Baseline | ||
| INH (not outbreak strain) | 1.23 | 0.72–2.11 | 0.441 |
| INH (outbreak strain) | 0.96 | 0.37–2.50 | 0.929 |
| MDR | 2.90 | 1.44–5.78 | 0.003 |
| Sought treatment at ED | 3.33 | 2.20–4.82 | <0.001 |
*OR, odds ratio; CI, confidence interval; INH, isoniazid resistant; MDR, multidrug-resistant; ED, emergency department.
