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Volume 14, Number 9—September 2008


Excretion of Transmissible Spongiform Encephalopathy Infectivity in Urine

Luisa Gregori, Gabor G. Kovacs, Irina Alexeeva, Herbert Budka, and Robert G. RohwerComments to Author 
Author affiliations: Veterans Affairs Medical Center, Baltimore, Maryland, USA (L. Gregori, I. Alexeeva, R.G. Rohwer); University of Maryland, Baltimore (L. Gregori, R.G. Rohwer); Medical University of Vienna, Vienna, Austria (G.G. Kovacs, H. Budka);

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Table 1

Titer of urine from scrapie-infected hamsters

Hamster Volume 
assayed, mL Fold dilution Volume inoculated, mL Total no. hamsters No. infected hamsters Titer, ID/mL* SD†
Infected 4.87 3 14.6 292 18 3.8 0.9
Noninoculated 2 None 2 40 1

*ID, infectious dose. Titer = –ln(P(0)) × (1/v), where P(0) = (noninfected animals)/(total animals inoculated) and v = inoculation volume, 0.05 mL.
†SD = square root (titer/V), where V = 4.87 mL, the total volume of the undiluted urine inoculated (1).

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