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Volume 14, Number 9—September 2008

Research

Excretion of Transmissible Spongiform Encephalopathy Infectivity in Urine

Luisa Gregori, Gabor G. Kovacs, Irina Alexeeva, Herbert Budka, and Robert G. RohwerComments to Author 
Author affiliations: Veterans Affairs Medical Center, Baltimore, Maryland, USA (L. Gregori, I. Alexeeva, R.G. Rohwer); University of Maryland, Baltimore (L. Gregori, R.G. Rohwer); Medical University of Vienna, Vienna, Austria (G.G. Kovacs, H. Budka);

Main Article

Table 1

Titer of urine from scrapie-infected hamsters

Hamster Volume 
assayed, mL Fold dilution Volume inoculated, mL Total no. hamsters No. infected hamsters Titer, ID/mL* SD†
Infected 4.87 3 14.6 292 18 3.8 0.9
Noninoculated 2 None 2 40 1

*ID, infectious dose. Titer = –ln(P(0)) × (1/v), where P(0) = (noninfected animals)/(total animals inoculated) and v = inoculation volume, 0.05 mL.
†SD = square root (titer/V), where V = 4.87 mL, the total volume of the undiluted urine inoculated (1).

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