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Volume 14, Number 9—September 2008

Research

Excretion of Transmissible Spongiform Encephalopathy Infectivity in Urine

Luisa Gregori, Gabor G. Kovacs, Irina Alexeeva, Herbert Budka, and Robert G. RohwerComments to Author 
Author affiliations: Veterans Affairs Medical Center, Baltimore, Maryland, USA (L. Gregori, I. Alexeeva, R.G. Rohwer); University of Maryland, Baltimore (L. Gregori, R.G. Rohwer); Medical University of Vienna, Vienna, Austria (G.G. Kovacs, H. Budka);

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Table 2

End-point dilution titration of urinary bladder and kidney from scrapie-infected hamsters

Dilution Total/no. infected
Bladder Kidney
10–1 19/19 4/4
10–1.3 8/8 20/20
10–1.7 8/8 8/8
10–2 4/4 8/8
10–3 4/4 4/3
10–4 4/2 4/1
10–5 4/1 4/0
10–6 4/0 4/0
Titer (log10 ID50/g)* 5.5 5.0
Standard error 0.5 0.4

*ID50, 50% infectious dose. Titers calculated by the Reed and Muench method (13); standard errors by the Pizzi method (14).

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