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Volume 15, Number 1—January 2009

Letter

Vertical Transmission of Pneumocystis jirovecii in Humans

Marco A. Montes-CanoComments to Author , Magali Chabe, Maria Fontillon-Alberdi, Carmen de la Horra, Nieves Respaldiza, Francisco J. Medrano, Jose M. Varela, Eduardo Dei-Cas, and Enrique J. Calderon
Author affiliations: Virgen del Rocío University Hospital, Seville, Spain (M.A. Montes-Cano, M. Fontillon-Alberdi, C. de la Horra, N. Respaldiza, F.J. Medrano, J.M. Varela, E.J. Calderon); Center for Biomedical Research in Epidemiology and Public Health, Seville (M.A. Montes-Cano, M. Fontillon-Alberdi, C. de la Horra, N. Respaldiza, F.J. Medrano, J.M. Varela, E.J. Calderon); Lille Pasteur Institute, Lille, France (M.A. Montes-Cano, M. Chabe, E. Dei-Cas)

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Table

Pneumocystis jirovecii genotypes in samples identified as positive by nested PCR for 2 loci from fetal lung tissues and placenta samples*

Case Lung tissues
Placenta tissues
mtLSU-rRNA genotype DHPS genotype mtLSU-rRNA genotype DHPS genotype
C1 3 1
C2 1 1 1
C3 3 1
C4 3 1
C5 2 1 1
C6 1 1 3
C7 1 1
C8 1 1
C9 3
C10 3
C11 3 1 and 3
C12 1 and 3 1
C13 1
C14 3
C15-C20

*Genotype 1, polymorphism 85C/248C in mitochondrial large subunit (mtLSU)–rRNA gene and 55 Trh/57 Pro indihydropteroate synthase (DHPS) gene; genotype 2, polymorphism in 85A/248C; genotype 3, polymorphism in 85T/248C.

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