Florence Legrand-Abravanel, Jean-Michel Mansuy, Martine Dubois, Nassim Kamar, Jean-Marie Peron, Lionel Rostaing, and Jacques Izopet
Author affiliations: Institut National de la Santé et de la Recherche Médicale, Toulouse, France (F. Legrand-Abravanel, M. Dubois, L. Rostaing, J. Izopet); Centre Hospitalier Universitaire, Toulouse (F. Legrand-Abravanel, J.-M. Mansuy, M. Dubois, N. Kamar, J.-M. Peron, L. Rostaing, J. Izopet)
Figure 1. Phylogenetic relationship among hepatitis E virus (HEV) strains from southwestern France and reference strains available in GenBank based on a 348-nt sequence in the open reading frame 2 (A) and on a 383-nt sequence of HEV RNA–dependent RNA polymerase (B). Genetic distances were calculated by using the Kimura 2-parameter method; phylogenetic trees were plotted by the neighbor-joining method. The reproducibility of the branching pattern was tested by bootstrap analysis (1,000 replicates). Each branch was labeled with the GenBank accession number of the strain, the geographic area, and the host, if nonhuman, and the geographic area where the sequence was isolated. The genotype and subtype were identified according to Lu et al. (3). Scale bars represent nucleotide substitutions per site. Boldface indicates the G3 French strains.
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