Emerging Infectious Disease ISSN: 1080-6059

A Model-based Assessment of Oseltamivir Prophylaxis Strategies to Prevent Influenza in Nursing Homes

Carline van den Dool

, Eelko Hak, Marc J.M. Bonten¹, and Jacco Wallinga¹

Author affiliations: University Medical Center, Utrecht, the Netherlands (C. van den Dool, E. Hak, M.J.M. Bonten, J. Wallinga); University Medical Center, Groningen, the Netherlands (E. Hak); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (J. Wallinga)

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Figure 2

Effects of prophylaxis with oseltamivir on influenza virus infection and disease rates among nursing home patients. The effects of both postexposure and continuous prophylaxis strategies are shown for different proportions of resistant virus strains in the community and compared with a control setting without prophylaxis and resistance. Panels A and C, postexposure prophylaxis given to all patients; panel B and D, continuous prophylaxis for 8 weeks. BL, baseline.

Figure 2. Effects of prophylaxis with oseltamivir on influenza virus infection and disease rates among nursing home patients. The effects of both postexposure and continuous prophylaxis strategies are shown for different proportions of resistant virus strains in the community and compared with a control setting without prophylaxis and resistance. Panels A and C, postexposure prophylaxis given to all patients; panel B and D, continuous prophylaxis for 8 weeks. BL, baseline.

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¹These authors contributed equally to this article.

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