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Volume 15, Number 11—November 2009

Letter

Preexisting Immunity to Pandemic (H1N1) 2009

Zheng XingComments to Author  and Carol J. Cardona
Author affiliations: University of California, Davis, CA, USA (Z. Xing, C.J. Cardona); Medical School, Nanjing University, Nanjing, People’s Republic of China (Z. Xing)

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Table

Conserved MHC class I antigen-restricted epitopes present in HA and NP proteins of pandemic (H1N1) 2009 virus*

MHC antigen
Epitope
position
Sequence
Identified in selected
virus isolates
HA
HLA-A*0201 344–353 GLFGAIAGFI A/New Caledonia/20/1999 (H1N1)
A/Solomon Islands/3/2006 (H1N1)
A/Macau/229/2008 (H1N1)
A/Managua/254.01/2008(H1N1
NP
HLA-A1 44–52 CTELKLSDY A/Hong Kong/HKU4/2004 (H3N2)
HLA-A*0101 A/Canterbury/200/2004 (H3N2)
HLA-A3 265–273 ILRGSVAHK A/New Caledonia/20/1999 (H1N1)
A/New York/55/2004 (H3N2)
A/Managua/254.01/2008(H1N1)
A/Taiwan/2645/2006 (H1N1)
HLA-B27 380–393 ELRSRYWAIRTRSG A/New Caledonia/20/1999 (H1N1)
A/Taiwan/2645/2006 (H1N1)
A/Managua/254.01/2008(H1N1)
A/Florida/UR06-0383/2007(H1N1)
HLA-B27 174–184 RRSGAAGAAVK A/New Caledonia/20/1999 (H1N1)
A/New York/55/2004 (H3N2)
A/California/UR07-0067/2008 (H3N2)
A/Taiwan/2645/2006 (H1N1)
HLA-B*2705 357–370 KLSTRGVQIASNEN A/New Caledonia/20/1999 (H1N1)
A/New York/55/2004 (H3N2)
A/Hong Kong/HKU77/2005 (H3N2)
A/Managua/3153.01/2008 (H1N1)
HLA-B*2705 383–391 SRYWAIRTR A/New Caledonia/20/1999
A/Taiwan/2645/2006 (H1N1)
A/Managua/4537.03/2008 (H1N1)
A/Florida/UR07-0026/2008 (H1N1)
HLA-B*2702 381–388 LRSRYWAI A/New Caledonia/20/1999
A/Florida/UR06-0383/2007(H1N1)
HLA-B*4002 251–259 AEIEDLIFL A/Canterbury/200/2004 (H3N2)
A/Hong Kong/HKU71/2005 (H3N2)
HLA-B8 225–233 ILKGKFQTA A/New Caledonia/20/1999
A/California/UR07-0067/2008 (H3N2)
A/Taiwan/2645/2006 (H1N1)
HLA-B8 380–388 ELRSRYWAI A/New Caledonia/20/1999 (H1N1)
HLA-B*0801 A/Taiwan/2645/2006 (H1N1)
A/Managua/107.01/2008 (H1N1)
A/Florida/UR07-0026/2008 (H1N1)

*HA, hemagglutinin; NP, nucleoprotein; MHC, major histocompatibility complex; NA, neuraminidase. Epitope binding to and/or activation of specific lymphocytes prepared from human peripheral blood mononuclear cells (PBMC): MHC-tetramer staining; T-cell receptor binding; ELISPOT and intracellular cytokine staining (interferon γ), and/or 51Chromine release and killing have been demonstrated in published studies. Data on epitope characterization were collected from the Immune Epitope Database (IEDB; www.immuneepitope.org) (4).

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