Volume 15, Number 11—November 2009
Letter
Preexisting Immunity to Pandemic (H1N1) 2009
Zheng Xing
and Carol J. Cardona
and Carol J. CardonaTable
Conserved MHC class I antigen-restricted epitopes present in HA and NP proteins of pandemic (H1N1) 2009 virus*
| MHC antigen |
Epitope
position |
Sequence |
Identified in selected
virus isolates |
|---|---|---|---|
| HA | |||
| HLA-A*0201 | 344–353 | GLFGAIAGFI | A/New Caledonia/20/1999 (H1N1) A/Solomon Islands/3/2006 (H1N1) A/Macau/229/2008 (H1N1) A/Managua/254.01/2008(H1N1 |
| NP | |||
| HLA-A1 | 44–52 | CTELKLSDY | A/Hong Kong/HKU4/2004 (H3N2) |
| HLA-A*0101 | A/Canterbury/200/2004 (H3N2) | ||
| HLA-A3 | 265–273 | ILRGSVAHK | A/New Caledonia/20/1999 (H1N1) |
| A/New York/55/2004 (H3N2) | |||
| A/Managua/254.01/2008(H1N1) | |||
| A/Taiwan/2645/2006 (H1N1) | |||
| HLA-B27 | 380–393 | ELRSRYWAIRTRSG | A/New Caledonia/20/1999 (H1N1) |
| A/Taiwan/2645/2006 (H1N1) | |||
| A/Managua/254.01/2008(H1N1) | |||
| A/Florida/UR06-0383/2007(H1N1) | |||
| HLA-B27 | 174–184 | RRSGAAGAAVK | A/New Caledonia/20/1999 (H1N1) |
| A/New York/55/2004 (H3N2) | |||
| A/California/UR07-0067/2008 (H3N2) | |||
| A/Taiwan/2645/2006 (H1N1) | |||
| HLA-B*2705 | 357–370 | KLSTRGVQIASNEN | A/New Caledonia/20/1999 (H1N1) |
| A/New York/55/2004 (H3N2) | |||
| A/Hong Kong/HKU77/2005 (H3N2) | |||
| A/Managua/3153.01/2008 (H1N1) | |||
| HLA-B*2705 | 383–391 | SRYWAIRTR | A/New Caledonia/20/1999 |
| A/Taiwan/2645/2006 (H1N1) | |||
| A/Managua/4537.03/2008 (H1N1) | |||
| A/Florida/UR07-0026/2008 (H1N1) | |||
| HLA-B*2702 | 381–388 | LRSRYWAI | A/New Caledonia/20/1999 |
| A/Florida/UR06-0383/2007(H1N1) | |||
| HLA-B*4002 | 251–259 | AEIEDLIFL | A/Canterbury/200/2004 (H3N2) |
| A/Hong Kong/HKU71/2005 (H3N2) | |||
| HLA-B8 | 225–233 | ILKGKFQTA | A/New Caledonia/20/1999 |
| A/California/UR07-0067/2008 (H3N2) | |||
| A/Taiwan/2645/2006 (H1N1) | |||
| HLA-B8 | 380–388 | ELRSRYWAI | A/New Caledonia/20/1999 (H1N1) |
| HLA-B*0801 | A/Taiwan/2645/2006 (H1N1) | ||
| A/Managua/107.01/2008 (H1N1) | |||
| A/Florida/UR07-0026/2008 (H1N1) |
*HA, hemagglutinin; NP, nucleoprotein; MHC, major histocompatibility complex; NA, neuraminidase. Epitope binding to and/or activation of specific lymphocytes prepared from human peripheral blood mononuclear cells (PBMC): MHC-tetramer staining; T-cell receptor binding; ELISPOT and intracellular cytokine staining (interferon γ), and/or 51Chromine release and killing have been demonstrated in published studies. Data on epitope characterization were collected from the Immune Epitope Database (IEDB; www.immuneepitope.org) (4).
