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Volume 15, Number 2—February 2009

Dispatch

Vaccine-induced Immunity Circumvented by Typical Mycobacterium tuberculosis Beijing Strains

Kristin KremerComments to Author , Marieke J. van der Werf, Betty K.Y. Au, Dang D. Anh, Kai M. Kam, H. Rogier van Doorn, Martien W. Borgdorff, and Dick van Soolingen
Author affiliations: National Institute for Public Health and the Environment, Bilthoven, the Netherlands (K. Kremer, B.K.Y. Au, D. van Soolingen); KNCV Tuberculosis Foundation, The Hague, the Netherlands (M.J. van der Werf, M.W. Borgdorff); National Institute of Hygiene and Epidemiology, Hanoi, Vietnam (D.D. Anh); Department of Health, Hong Kong Special Administrative Region, People’s Republic of China (K.M. Kam); University of Amsterdam, Amsterdam, the Netherlands (H.R. van Doorn, M.W. Borgdorff)

Main Article

Table 1

Risk factors for atypical Mycobacterium tuberculosis in 678 Beijing strain–infected persons with tuberculosis, Vietnam and the Netherlands

Risk factor Total no. patients infected with Beijing clade No. (%) patients infected with atypical Beijing strain Odds ratio (95% confidence interval)
Crude Adjusted*
Country
Vietnam 268 68 (25.4) 1 1
The Netherlands 410 87 (21.2) 0.79 (0.55–1.14) 0.82 (0.52–1.29)
Sex
M 415 93 (22.4) 1 1
F 219 48 (21.9) 0.97 (0.66–1.44) 1.01 (0.67–1.51)
Unknown 44 14 (31.8) 1.62 (0.82–3.17) 1.92 (0.90–4.11)
Age, y
<25 164 36 (22.0) 1 1
25–34 215 51 (23.7) 1.11 (0.68–1.80) 1.05 (0.64–1.73)
35–44 140 29 (20.7) 0.93 (0.54–1.61) 0.80 (0.45–1.42)
45–54 51 7 (13.7) 0.57 (0.24–1.36) 0.45 (0.18–1.12)
55–64 36 9 (25.0) 1.19 (0.51–2.75) 1.03 (0.44–2.45)
65–74 50 13 (26.0) 1.25 (0.60–2.60) 1.07 (0.50–2.30)
>75 22 10 (45.5) 2.96 (1.18–7.41) 2.96 (1.15–7.67)
BCG† vaccination
No 249 69 (27.7) 1 1
Yes 265 55 (20.8) 0.68 (0.46–1.03) 0.60 (0.38–0.95)
Unknown 164 31 (18.9) 0.61 (0.38–0.98) 0.61 (0.36–1.04)
Total 678 155 (22.8)

*Adjusted for country, sex, age group, and BCG vaccination.
†BCG, Mycobacterium bovis bacillus Calmette-Guérin.

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