Volume 15, Number 2—February 2009
Dispatch
Clinical Relevance of Nontuberculous Mycobacteria, Oman
, Suleiman Al-Busaidy, Martin J. Boeree, Samiya Al-Zadjali, Arti Patel, P.N. Richard Dekhuijzen, and Dick van SoolingenTable
Clinical and microbiologic data for 13 patients with Mycobacterium spp. infections, Oman, 2006–2007*
| Patient no./sex/ age, y | Species | AFB smear | Positive cultures | Source | Condition | Symp. | Chest radiograph | 2007 ATS criteria | Therapy | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|
| 1/F/64 | M. intracellulare† | + | Multiple | Sputum | – | PC, F, WL, CP, M | NP | Met | HRZE | Improved |
| 2/M/29 | MAIS complex | + | Single | Sputum | – | PC, Hp, WL | Cavities | Met | HRZE | Improved |
| 3/F/31 | M. chimaera‡ | – | Multiple | Sputum | – | None | RUL bronch. | Not met | None | Stable |
| 4/M/28 | M. chimaera‡ | + | Multiple | Sputum | – | PC, WL | RUL multiple scars, left lung destroyed, abscess, PT | Met | SClaCip | Failure |
| 5/M/18 | 16S: M. colombiense | – | Single | BAL | HD | PC, Hp, CP | NP | Met | HRE | Improved |
| 6/M/57 | 16S: M. flavescens | NP | Single | Urine | – | AP | NP | Not met | NA | NA |
| 7/F/57 | M. simiae | – | Single | Sputum | HIV | PC | Patchy opacities in LUL and lingula | Met | HRE | Improved |
| 8/F/12 | M. kansasii III/IV/V | – | Single | Sputum | – | None | Normal | Not met | NA | NA |
| 9/M/43 | M. tuberculosis and M. intracellulare† | + | Multiple | Sputum | – | PC, F, WL, M | Cavities | NA | HRZES | Failure |
| 10/F/7 | M. marinum | – | Single | Skin | – | Skin lesion | NP | Met | ECla | Improved |
| 11/F/65 | M. chimaera‡ | + | Multiple | Sputum | – | PC, BA | Destroyed left lung | Met | ClaCip | Improved |
| 12/F/83 | M. avium | – | Single | Sputum | – | None | RUL infiltration | Not met | NA | NA |
| 13/M/63 | M. intracellulare† | + | Single | Sputum | Prior PNTM disease | PC, WL, M | Bronch., PI | Met | RECip | Improved |
*AFB, acid-fast bacilli; Symp., symptoms; ATS, American Thoracic Society; PC, productive cough; F, fever; WL, weight loss; CP, chest pain; M, malaise/fatigue; NP, not performed; H, isoniazid; R, rifampicin; Z, pyrazinamide; E, ethambutol; MAIS, M. avium–intracellulare–scrofulaceum; Hp, hemoptysis; RUL, right upper lobe of lung; LUL, left upper lobe of lung; Bronch., bronchiectasis; PT, pleural thickening; S, streptomycin; Cla, clarithromycin; Cip, ciprofloxacin; 16S, identified by 16S rDNA gene sequencing; BAL, bronchoalveolar lavage fluid; HD, heart disease; AP, abdominal pain; NA, not applicable; BA, backache; PI, parenchymal infiltration; PNTM, pulmonary nontuberculous mycobacteria.
†Reaction with the MIN-1 probe; M. intracellulare sequevar Min-A, -B, -C, or -D.
‡Reaction with the MIN-2 probe; M. intracellulare sequevar MAC-A, which was recently elevated to the species level (M. chimaera) (7).
