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Volume 15, Number 2—February 2009

Research

Characteristics of 263K Scrapie Agent in Multiple Hamster Species

Kimberly D. Meade-WhiteComments to Author , Kent D. Barbian, Brent Race, Cynthia Favara, Don Gardner, Lara Taubner, Stephen Porcella, and Richard Race
Author affiliations: National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA

Main Article

Table

Average incubation period for 263K scrapie*

Hamster species† Cross-species 263K
Second passage
Third passage
Back passage‡
Dpi ± SD Titer/50 μL (1% BH) Dpi Titer/50 μL (1% BH) Dpi Titer/50 μL (1% BH) Dpi
Syrian 85 2 x 109 ND ND ND ND 79 ± 5
Turkish 91 ± 4.9 1 x 108.9 103 ± 7.2 1 x 106.7 85 ± 7.6 1 x 108.25 76 ± 0
Djungarian 155 ± 23.4 1 x 108.4 100 ± 9.0 1 x 109.6 99 ± 7.2 1 x 109.7 97 ± 7
Siberian 148 ± 26.5 1 x 108.3 117 ± 9.9 1 x107.75 114 ± 8.3 1 x 108.1 128 ± 17
Chinese 372 ± 29.1 ND 233 ± 17.9 ND 207 ± 15.2 ND 168 ± 7
Armenian 188 ± 10.4 1 x 107.35 156 ±4.8 1 x 107.75 145 ±7.5 >1 x 108.5 145 ± 18

*Dpi, days postinoculation; ND, not done; BH, brain homogenate.
†16 hamsters/species.
‡In Syrian hamster.

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