Integron-mediated Multidrug Resistance in a Global Collection of Nontyphoidal Salmonellaenterica Isolates
Mary G. Krauland, Jane W. Marsh, David L. Paterson, and Lee H. Harrison
Author affiliations: University of Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, Pennsylvania, USA (M.G. Krauland, J.W. March, D.L. Paterson, L.H. Harrison); University of Queensland, Royal Brisbane and Women’s Hospital, Brisbane, Queensland, Australia (D.L. Paterson)
Figure. Minimum spanning trees depicting integron distribution across Salmonella enterica genetic lineages. A) dfrA12/orfF/aadA2; B) dfrA7; C) dfrA1/aadA1; D) arr2/blaOXA30/cmlA5/aadA2. Circles represent unique sequence types (STs). Red circles represent the STs that carried the integron involved in horizontal gene transfer. Numbers in circles represent the ST. Circle size reflects number of isolates in each ST. Pink and green shading indicates closely related groups of isolates. Letters refer to serotypes: B, Brandenburg; C, Cholerasuis; E, Enteriditis; H, Heidelberg; G, Goettingen; I, Isangi; P, Paratyphi A; Z, Schwarzengrund; Y, Stanley; T, Typhimurium. Geographic sources of isolates are as follows: Panel A: ST66, serotype C, Taiwan; ST29, serotype C, Taiwan; ST29, serotype Y, Taiwan; ST96, serotype Z, Denmark and Taiwan; ST19, serotype T, US Centers for Disease Control and Prevention and South Africa; ST15, serotype H, Philippines; Panel B: ST11, serotype E, Uganda and South Africa; ST85, serotype P, Denmark; Panel C: ST334, serotype G, Spain; ST334, serotype B, Spain; ST34, serotype T, Germany; Panel D: ST19, serotype T, South Africa; ST216, ST335, ST336, and ST 337, serotype I, South Africa.
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