High Prevalence of Spirochetosis in Cholera Patients, Bangladesh
Eric J. Nelson, Angela Tanudra, Ashrafuzzaman Chowdhury, Anne V. Kane, Firdausi Qadri, Stephen B. Calderwood, Jenifer Coburn, and Andrew Camilli
Author affiliations: Howard Hughes Medical Institute–Tufts University School of Medicine, Boston, Massachusetts, USA (E.J. Nelson, A. Camilli); Medical College of Wisconsin, Milwaukee, Wisconsin, USA (A. Tanudra, J. Coburn); Tufts Medical Center, Boston (A. Tanudra, A.V. Kane, J. Coburn); Jahangirnagar University, Dhaka, Bangladesh (A. Chowdhury); International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka (F. Qadri); Massachusetts General Hospital, Boston (S.B. Calderwood); Harvard Medical School, Boston (S.B. Calderwood)
Figure. Neighbor-joining (NJ) phylogeny of NADH oxidase (nox) sequences of Brachyspira pilosicoli from 5 cholera patients (A–E). The nox sequences were PCR amplified, cloned, and sequenced from each patient (individual clones are appended _SX). Published sequences from known species are included for reference. NJ analysis was performed by using an NJ model and 1,000 bootstraps. Bootstrap values >800 are presented next to nodes. The scale bar indicates a 2% bp change (contiguous sequence ≈990 bp).
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