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Volume 15, Number 4—April 2009


Enterovirus 71 Maternal Antibodies in Infants, Taiwan

Shu-Ting Luo, Pai-Shan Chiang, An-Shine Chao, Guan-Yuan Liou, Reyin Lin, Tzou-Yien Lin, and Min-Shi LeeComments to Author 
Author affiliations: National Health Research Institutes, Zhunan Miaoli, Taiwan (S.-T. Luo, P.-S. Chiang, G.-Y. Liou, M.-S. Lee); Chang Gung Memorial Hospital, Linkou, Taiwan (A.-S. Chao, R. Lin, T.-Y. Lin)

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Table 2

Biological half-life of maternal enterovirus 71 neutralizing antibodies in 154 seropositive neonates, determined by cross-sectional and longitudinal analyses, Taiwan*

Antibody titers at 6 mo of age No. GMT at birth (SD†) GMT at 6 mo Cross-sectional mean half-life‡ Longitudinal mean half-life§
Detectable 3 203 8 39 42
Undetectable 151 21 2 53 60
Total 154 22 (0.91) 2 53 60

*GMT, geometric mean titer.
†After natural logarithm transformation.
‡Calculated on the basis of the GMT at birth and 6 months of age. For comparison, half-life is reported in days, assuming that1 month is equal to 30 days.
§Calculated on the basis of paired antibody titers in each individual.

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