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Volume 15, Number 5—May 2009

Letter

Near-Fatal Multiple Organ Dysfunction Syndrome Induced by Plasmodium malariae

Pierre-Néri DescheemaekerComments to Author , Jean-Paul Mira, Fabrice Bruneel, Sandrine Houzé, Michèle Tanguy, Jean-Pierre Gangneux, Erwan Flecher, Christophe Rousseau, Jacques Le Bras, and Yannick Mallédant
Author affiliations: Hôpital Pontchaillou, Université de Rennes 1, Rennes, France (P.-N. Descheemaeker, M. Tanguy, J.-P. Gangneux, E. Flecher, Y. Mallédant); Hôpital Cochin, Port-Royal, Paris, France (J.-P. Mira, C. Rousseau); Centre Hospitalier de Versailles, Versailles, France (F. Bruneel); Hôpital Bichat Claude-Bernard, Paris (S. Houzé, J. Le Bras)

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Table

Results of genetic screening for single nucleotide polymorphisms known to be associated with sepsis severity in patient with Plasmodium malariae infection, France*

Gene rs Wild type Heterozygous Homozygous
Pathogen detection
TLR2 5743708 X
TLR2 5743704 X
TLR4 4986790 X
TLR5 5744168 X
CD14 2569190 X
MD-2 –1625C/G X
FcγRIIa 1801274 X
MBL2 52 A/D X
MBL2 54 A/B X
MBL2 57 A/C X
MBL2 –550 H/L X
MBL2 –221 X/Y X
MBL2
+4 P/Q
X


TLR signaling
IRAK1 1059703 X
TIRAP 8177374 X
IκB 3138053 X
IκB
2233406

X

Inflammation
Lymphotoxin α 909253 X
TNF α 1800629 X
ACE 17236674 X
MIF 755622 X
IL-6 1800795 X
IL-10
1800896
X


Coagulation
PAI-1 1799768 X
Factor V 6025 X

*Except for MD-2 and MBL2, rs is the nomenclature used to describe the variants (initially described by den Dunnen and Antonarakis [4]). TLR, toll-like receptor; MBL2, mannose-binding lectin 2; IRAK-1, interleulin-1 receptor-associated kinase; TIRAP, toll interleukin-1 receptor-associated protein; IκB:, inhibitor of Nf-κB; TNF, tumor necrosis factor; ACE, angiotensin-converting enzyme; MIF, macrophage migration inhibitory factor; IL, interleukin; PAI-1, plaminogen activator inhibitor-1.

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