Emerging Infectious Disease ISSN: 1080-6059

Virulent Strain of Hepatitis E Virus Genotype 3, Japan

Kazuaki Takahashi

, Hiroaki Okamoto, Natsumi Abe, Manri Kawakami, Hiroyuki Matsuda, Satoshi Mochida, Hiroshi Sakugawa, Yoshiki Suginoshita, Seishiro Watanabe, Kazuhide Yamamoto, Yuzo Miyakawa, and Shunji Mishiro

Author affiliations: Toshiba General Hospital, Tokyo, Japan (K. Takahashi, N. Abe, S. Mishiro); Jichi Medical University School of Medicine, Tochigi, Japan (H. Okamoto); Kurashiki Medical Center, Okayama, Japan (M. Kawakami); Matsuda Naika Clinic, Tottori, Japan (H. Matsuda); Saitama Medical University, Saitama, Japan (S. Mochida); Heart-Life Hospital, Okinawa, Japan (H. Sakugawa); Kyoto University Graduate School of Medicine, Kyoto, Japan (Y. Suginoshita); Kagawa Prefectural Central Hospital, Kagawa, Japan (S. Watanabe); Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama (K. Yamamoto); Miyakawa Memorial Research Foundation, Tokyo (Y. Miyakawa)

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Appendix Figure

Alignment of a partial C-terminal amino acid sequence of the helicase domain of hepatitis E virus (HEV) open reading frame (ORF) 1 across genotype 3 and 4 isolates. A bracket indicates 8 isolates of the JIO strain HEV genotype 3 and 5 isolates of swJ19 strain. Conversions in helV239A are shown by linear box. Partial sequences of ORF1 (aa positions 1105-1226 of HEV-US2) of human and swine isolates of genotype 3 were compared.

Appendix Figure. Alignment of a partial C-terminal amino acid sequence of the helicase domain of hepatitis E virus (HEV) open reading frame (ORF) 1 across genotype 3 and 4 isolates. A bracket indicates 8 isolates of the JIO strain HEV genotype 3 and 5 isolates of swJ19 strain. Conversions in helV239A are shown by linear box. Partial sequences of ORF1 (aa positions 1105-1226 of HEV-US2) of human and swine isolates of genotype 3 were compared.

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