Cowpox Virus Transmission from Pet Rats to Humans, Germany
Hartmut Campe1, Pia Zimmermann1, Katharina Glos, Margot Bayer, Hans Bergemann, Caroline Dreweck, Petra Graf, Bianca Kim Weber, Hermann Meyer, Mathias Büttner, Ulrich Busch, and Andreas Sing
Author affiliations: Bavarian Health and Food Safety Authority, Oberschleißheim, Germany (H. Campe, P. Zimmermann, M. Bayer, B.K. Weber, M. Büttner, U. Busch, A. Sing); Haas & Link Tierärztliche Fachklinik für Kleintiere, Germering, Germany (K. Glos); Local Health District Authority, Dachau, Germany (H. Bergemann); Department of Health and Environment, State Capital, Munich, Germany (C. Dreweck, P. Graf); Bundeswehr Institute for Microbiology, Munich (H. Meyer); 1These authors contributed equally to this article.
Figure 2. Phylogenetic tree of the isolated cowpox virus (CPXV) Shiva strain (in boldface; named after pet rat shown in Figure 1, panel A; GenBank accession no. FJ654467), constructed by the maximum-parsimony method based on the partial sequences method based on the hemagglutinin (HA) gene, unrooted. BLAST search (www.ncbi.nlm.nih.gov/blast/Blast.cgi) confirmed the identification of this strain as a CPXV strain with a unique HA gene sequence. The highest identity of 98.1% was found for strain cowHA72 (accession no. AY902300), a CPXV strain isolated from an elephant in the Netherlands. Bootstrap values >50% are shown. Additional unique CPXV strains shown for comparison, by accession number: AY902307 (cowHA35e), AY902301 (cowHA82), AY902299 (cowHA70), AY902298 (cowHA68), AY902297 (cowHA52), AY902296 (cowHA51), AY902295 (cowHA48), AY902294 (cowHA46), AY902289 (cowHA47), AY902288 (cowHA41), AY902287 (cowHA40), AY902286 (cowHA37), AY902279 (cowHA76), AY902276 (cowHA23), AY902308 (cowHA38), AY902275 (cowHA22), AY902274 (cowHA21), AY902273 (cowHA81), AY902271 (cowHA19), AY902270 (cowHA18), AY902269 (cowHA17), AY902268 (cowHA16), AY902263 (cowHA15), AY902262 (cowHA34), AY902260 (cowHA13), AY902257 (cowHA09), AY902256 (cowHA07), AY902255 (cowHA63), AY902252 (cowHA73), AY944029 (CPV90_ger2), AY944028 (CPV91_ger3), AF377886 (cowpox virus), AF377885 (cpv-922-99), AF377884 (cpv-867-99b), AF377883 (cpv-667-94b), AF377877 (cpv-1218-00), AF375090 (cpx-ep-2), AF375089 (cpx-brt), AF375088 (cpx-90-5), AF375087 (CPX-90-1), AF375086 (cpx-89-5), AF375085 (cpx-89-4), and AF375084 (cpx-89-1).
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