Figure 1. Cowpox virus infection in 3 persons in northern France caused by transmission from infected pet rats. Cutaneous lesions caused by cowpox virus are shown in patient 1 (A), patient 3 (B) and patient 4 (C, D). The 2 latter patients had lymphangitis associated with the local lesion. Panel C was obtained on January 30, 2009, panel D on February 6, 2009. Negative-staining electron microscopy showed mulberry forms with conspicuous but short, randomly arranged surface tubules (E) and capsule forms with deeper stain penetration (F), both highly suggestive of poxvirus. Scale bar for panels E and F = 100 nm.