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Volume 15, Number 7—July 2009

Dispatch

Recurrent Lymphocytic Meningitis Positive for Herpes Simplex Virus Type 2

Katariina Kallio-LaineComments to Author , Mikko Seppänen, Hannu Kautiainen, Marja-Liisa Lokki, Maija Lappalainen, Ville Valtonen, Markus Färkkilä, and Eija Kalso
Author affiliations: Helsinki University Central Hospital, Helsinki, Finland (K. Kallio-Laine, M. Seppänen, M. Lappalainen, V. Valtonen, M. Färkkilä, E. Kalso); Orton Orthopedic Hospital, Helsinki (H. Kautiainen); Haartman Institute, University of Helsinki, Helsinki (M.-L. Lokki)

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Table 1

Presence of HSV type 2 DNA in CSF, leukocyte count, and timing of CSF samples in 22 patients with recurrent lymphocytic meningitis, through December 2007, Finland*

Patient no. Age, y No. episodes Period 
(first episode–latest episode) HSV-2 DNA in CSF Leukocyte counts and timing of CSF samples in PCR-tested cases
1 29 7 2000–2004 NT, P, NP, NT, NP, NP, NP 44,† 18,‡ 4,‡ 2,‡ 1§
2 55 9 1985–2004 NT, NT, NT, NT, NT, P, P, NP, NP 219221,§ 9,† 3†
3 44 4 1990–1998 NT, NT, NT, P 310§
4 43 4 1988–2000 NT, NT, NT, P 790§
5 33 4 1994–1998 NT, P, P, P 1,410,§ ¶,§ 73§
6 32 4 1996–2002 P, NP, NP, NP 164,§ 64,† 32,† 93†
7 48 5 1979–2002 NT, NT, NT, P, NT 196§
8 33 4 1998–2005 NT, P, NP, NP 360,† 238,§ 239#
9 36 13 1990–2007 NT, NT, NT, NT, NT, NT, NT, NT, P, NP, NP, NP, NP 195,§ 2,† 0,† 260,§ 1‡
10 40 4 1990–1994 NT, NT, P, NT 40
11 47 2 2001–2003 P, NP 1,006,§ 790§
12 40 2 1989–1997 NT, P 325§
13 36 2 2001–2004 P, P 592620§
14 38 2 1991–1996 NT, P 92§
15 51 3 1975–1998 NT, NT, P 680
16 38 7 1992–2006 NT, P, NT, NP, NT, NT, P 160,† 16,‡ 106§
17 51 3 1984–1998 NT, NT, P 360
18 39 3 1989–2004 NT, NT, P 172§
19 45 5 1980–2004 NT, NT, NT, P,P 350203§
20 25 2 2002–2004 P, NP 1,350,§ 430§
21 33 4 1995–2007 P,P, P, NT 720306,§ ¶§
22 38 2 1990–1999 NT, P 645

*HSV, herpes simplex virus; CSF, cerebrospinal fluid; NT, HSV DNA not tested; P, HSV-2 DNA present in CSF; NP, HSV-2 DNA not present in CSF. Boldface indicates HSV-2 DNA present in the sample.
†CNF sample taken 24–48 h after first symptoms.
‡CSF sample taken within 24 h of the first symptoms.
§CSF sample taken 2–5 days after first symptoms.
¶Leukocyte count or timing of the sample not known.
#CSF sample taken >5 days after first symptoms.

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