Skip directly to search Skip directly to A to Z list Skip directly to site content
CDC Home

Volume 15, Number 9—September 2009


Merkel Cell Polyomavirus DNA in Persons without Merkel Cell Carcinoma

Ulrike WielandComments to Author , Cornelia Mauch, Alexander Kreuter, Thomas Krieg, and Herbert Pfister
Author affiliations: Institute of Virology, Koeln, Germany (U. Wieland, H. Pfister); Department of Dermatology, Koeln (C. Mauch, T. Krieg); Department of Dermatology, Bochum, Germany (A. Kreuter)

Main Article

Table 1

MCPyV DNA in biopsies of immunocompetent patients without MCC*

Histologic diagnosis No. samples No. (%) MCPyV-positive by nested PCR
Papilloma/wart 4 0 (0)
Actinic keratosis 7 0 (0)
Keratoacanthoma 7 3 (43)
Squamous cell carcinoma 6 1 (17)
Bowen disease/carcinoma 4 1 (25)
Basal cell carcinoma 21 3 (14)
Malignant melanoma 12 2 (17)
All skin tumors 61 10 (16)
Perilesional healthy skin 34 8 (24)

*MCPyV, Merkel cell polyomavirus; MCC, Merkel cell carcinoma. All samples shown were negative for Merkel cell polyomavirus in single-round PCR. Six MCPyV-positive perilesional samples had an MCPyV-positive lesional counterpart (3 basal cell carcinomas, 2 keratoacanthomas, 1 squamous cell carcinoma); 1 MCPyV-positive perilesional biopsy had a MCPyV-negative counterpart (basal cell carcinoma); and of 1 MCPyV-positive perilesional biopsy the lesional counterpart was not available. For origin of samples see (7).

Main Article

Top of Page The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30333, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO