Phylogeny and Disease Association of Shiga Toxin–producing Escherichia coli O91
Alexander Mellmann , Angelika Fruth, Alexander W. Friedrich, Lothar H. Wieler, Dag Harmsen, Dirk Werber, Barbara Middendorf, Martina Bielaszewska, and Helge Karch
Author affiliations: Institute of Hygiene and the National Consulting Laboratory on Hemolytic Uremic Syndrome, Münster, Germany (A. Mellman, A.W. Friedrich, D. Harmsen, B. Middendorf, M. Bielaszewska, H. Karch); Department of Periodontolgy, Münster (D. Harmsen); Robert Koch Institute, Wernigerode, Germany (A. Fruth); Free University Berlin, Berlin, Germany (L.H. Wieler); Robert Koch Institute, Berlin (D. Weber)
Figure. Minimum spanning tree based on the multilocus sequence typing allelic profiles portraying the clonal distribution of the 100 Escherichia coli O91:H8/H10/H14/H21/H–/Hnt isolates (highlighted in gray) associated with different diseases in relation to the hemolytic uremic syndrome–associated enterohemorrhagic E. coli collection. Each dot represents a given sequence type, and the size of each circle is proportional to the number of strains analyzed. Connecting lines show the number of identical alleles between 2 STs (thick black line, 6 of 7 alleles identical; thick gray line, 5 alleles identical; thick dashed line, 4 alleles identical; thin dashed lines of increasing length, <3 alleles identical).
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